Results 71 to 80 of about 666,866 (314)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Inequalities of Standardized Testing

open access: yes, 2022
Minorities in America are constantly facing inequalities throughout different portions of their life. The school system is is an area of these inequalities that does not get enough attention to work to change it.
Mcshane, Megan
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Assessment of In Vitro Release Testing Methods for Colloidal Drug Carriers: The Lack of Standardized Protocols

open access: yes
Although colloidal carriers have been in the pipeline for nearly four decades, standardized methods for testing their drug-release properties remain to be established in pharmacopeias. The in vitro assessment of drug release from these colloidal carriers
Aparicio Blanco, Juan   +7 more
core   +1 more source

Current Status of English as a Foreign Language Evaluation in Colombia

open access: yesCuadernos de Lingüística Hispánica
This article presents the current status of bibliographical production of the research in the field of assessment of English as a foreign language in Colombia. A collection and analysis of the main Colombian academic production related to the principles,
Katherin Pérez-Rojas   +1 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Negative Effects of Standardized Testing

open access: yes, 2019
This Capstone Project focused on the negative effects of standardized testing and the alternatives. The participants for this project consisted of 32 third-graders in a public elementary school located in Southern California.
Brown, Brianna
core  

School-Related Influences on Grade 8 Mathematics Performance in Massachusetts

open access: yesNonpartisan Education Review, 2005
Less than one third of American eighth graders score in the two highest performance levels on the grade 8 mathematics test given by the National Assessment of Educational Progress. Only a little over one third of Massachusetts eighth graders score at the
Eugene Warren   +2 more
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

An automated Model-based Testing Approach in Software Product Lines Using a Variability Language.

open access: yes, 2010
This paper presents the application of an automated testing approach for Software Product Lines (SPL) driven by its state-machine and variability models.
Parada Gélvez, Hugo Alexer   +5 more
core  

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