Results 91 to 100 of about 71,711 (296)

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha   +6 more
wiley   +1 more source

The Impact of Stellar Radiative Feedback on Formation of Young Massive Clusters via Fast H i Gas Collisions

open access: yesThe Astrophysical Journal
Young massive clusters (YMCs) are dense aggregates of young stars and are often speculated as potential precursors to globular clusters. However, the formation mechanism of massive and compact gas clumps that precede YMCs remains unknown.
Ryunosuke Maeda   +4 more
doaj   +1 more source

Star clusters in evolving galaxies [PDF]

open access: yesNew Astronomy Reviews, 2018
Their ubiquity and extreme densities make star clusters probes of prime importance of galaxy evolution. Old globular clusters keep imprints of the physical conditions of their assembly in the early Universe, and younger stellar objects, observationally resolved, tell us about the mechanisms at stake in their formation.
openaire   +4 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Revisit of 77 Clusters Candidates with Multiple Main Sequences using Gaia DR3

open access: yesThe Astronomical Journal
Gaia DR3 data provide the latest and full astrometric data for more than 1.5 billion sources, and these allow us to revisit the 77 special open cluster candidates collected from LISC star cluster catalog.
Jing Chen   +4 more
doaj   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

open access: yesMolecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou   +11 more
wiley   +1 more source

Evolution of Star Clusters within Galaxies Using Self-consistent Hybrid Hydro/N-body Simulations

open access: yesThe Astrophysical Journal
We introduce a GPU-accelerated hybrid hydro/ N -body code ( Enzo-N ) designed to address the challenges of concurrently simulating star clusters and their parent galaxies.
Yongseok Jo   +3 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

A Comprehensive Study of Open Cluster Chemical Homogeneity Using APOGEE and Milky Way Mapper Abundances

open access: yesThe Astrophysical Journal
Stars in an open cluster are assumed to have formed from a broadly homogeneous distribution of gas, implying that they should be chemically homogeneous.
Amaya Sinha   +6 more
doaj   +1 more source

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