Results 91 to 100 of about 71,766 (252)

Disk-locking Regulates Stellar Rotation in Young Clusters: Insights from NGC 2264

The Astrophysical Journal
Many young clusters possess extended main sequences, a phenomenon commonly ascribed to stellar rotation. However, the mechanism behind their very wide stellar rotation distributions remains unclear.
Yutian Bu, Chenyu He, Min Fang, Chengyuan Li   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A Comprehensive Study of Open Cluster Chemical Homogeneity Using APOGEE and Milky Way Mapper Abundances

The Astrophysical Journal
Stars in an open cluster are assumed to have formed from a broadly homogeneous distribution of gas, implying that they should be chemically homogeneous.
Amaya Sinha, Gail Zasowski, Peter Frinchaboy, Katia Cunha, Diogo Souto, Jamie Tayar, Keivan Stassun   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A Thorough Exploration of the Metal-rich Massive Open Cluster NGC 6253: Focusing on Membership, Binaries, Stragglers, and Mass Function

The Astrophysical Journal
This study provides an in-depth analysis of the ancient open galactic cluster NGC 6253, characterized by the presence of both blue and yellow straggler stars.
Huanbin Chi, Feng Wang
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A JWST Project on 47 Tucanae: NIRSpec Spectroscopy of Multiple Populations among M Dwarfs

The Astrophysical Journal Letters
We present the first spectroscopic estimates of the chemical abundance of M dwarf stars in a globular cluster (GC), namely 47 Tucanae. By exploiting NIRSpec on board the James Webb Space Telescope, we gathered low-resolution spectra for 28 stars with ...
A. F. Marino, A. P. Milone, A. Renzini, E. Dondoglio, E. Bortolan, M. G. Carlos, G. Cordoni, A. Dotter, S. Jang, E. P. Lagioia, M. V. Legnardi, F. Muratore, A. Mohandasan, M. Tailo, T. Ziliotto   +14 more
doaj   +1 more source

slug IV: a novel forward-modelling method to derive the demographics of star clusters. [PDF]

Mon Not R Astron Soc, 2019
Krumholz MR, Adamo A, Fumagalli M, Calzetti D.   +3 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source