Results 91 to 100 of about 44,874 (266)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Large-scale Mapping Observations of DCN and DCO+ toward Orion KL
The Astrophysical JournalWe present emission maps ( $1\buildrel{\,\prime}\over{.} 5\,\times \,1\buildrel{\,\prime}\over{.} 5$ scale, corresponding to 0.18 pc) of the DCN ( J = 2 − 1) and DCO ^+ ( J = 2 − 1) lines in the 2 mm band toward the Orion KL region obtained with the 2 mm
Kotomi Taniguchi +18 more
doaj +1 more source
Star Forming Regions in Cassiopeia
, 2008 This chapter describes the Galactic star forming regions in the constellation Cassiopeia, in the Galactic coordinate range 120 deg < l < 130 deg, -5 deg < b < +15 deg. At b > 10 deg the nearby clouds L1333 and L1340 are found in this region.
openaire +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Investigating the Influence of Radiative Feedback in the Bright-rimmed Cloud 44
The Astrophysical JournalRadiative feedback from massive stars plays a central role in the evolution of molecular clouds and the interstellar medium. This paper presents a multiwavelength analysis of the bright-rimmed cloud (BRC) 44, which is located at the periphery of the H ii
Rishi C +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Low-mass Stellar and Substellar Content of the Young Cluster Berkeley 59
The Astronomical JournalWe present a multiwavelength analysis of the young star cluster Berkeley 59, based on Gaia data and deep IR observations with the 3.58 m Telescopio Nazionale Galileo and Spitzer space telescope.
Neelam Panwar +6 more
doaj +1 more source