Results 101 to 110 of about 563,924 (339)

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Massive Star Formation in the Ultraviolet Observed with the Hubble Space Telescope

Galaxies, 2020
Spectroscopic observations of a massive star formation in the ultraviolet and their interpretation are reviewed. After a brief historical retrospective, two well-studied resolved star clusters and the surrounding H II regions are introduced: NGC 2070 in ...
Claus Leitherer
doaj   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Star-forming region BBW 36 in puppis

Astrophysics, 2008
Recent studies of the star formation region BBW 36 and associated molecular clouds are presented. The 12CO (1-0) observations, carried out with the 15-m SEST (Swedish-ESO) telescope (Cerro La Silla, Chile), revealed the existence of cloud a, connected with BBW 36 and of cloud b, having elongation in SE-NW direction. A red-shifted molecular outflow with
Gyulbudahgian, A. L., May Humeres, Jorge
openaire   +6 more sources

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Large-scale Mapping Observations of DCN and DCO+ toward Orion KL

The Astrophysical Journal
We present emission maps ( $1\buildrel{\,\prime}\over{.} 5\,\times \,1\buildrel{\,\prime}\over{.} 5$ scale, corresponding to 0.18 pc) of the DCN ( J = 2 − 1) and DCO ^+ ( J = 2 − 1) lines in the 2 mm band toward the Orion KL region obtained with the 2 mm
Kotomi Taniguchi, Prathap Rayalacheruvu, Teppei Yonetsu, Tatsuya Takekoshi, Bunyo Hatsukade, Kotaro Kohno, Tai Oshima, Yoichi Tamura, Yuki Yoshimura, Víctor Gómez-Rivera, Sergio Rojas-García, Arturo I. Gómez-Ruiz, David H. Hughes, F. Peter Schloerb, Liton Majumdar, Masao Saito, Iván Rodríguez-Montoya, David Sánchez-Arguelles, Ryohei Kawabe   +18 more
doaj   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Low-mass Stellar and Substellar Content of the Young Cluster Berkeley 59

The Astronomical Journal
We present a multiwavelength analysis of the young star cluster Berkeley 59, based on Gaia data and deep IR observations with the 3.58 m Telescopio Nazionale Galileo and Spitzer space telescope.
Neelam Panwar, Rishi C., Saurabh Sharma, Devendra K. Ojha, Manash R. Samal, H. P. Singh, Ram Kesh Yadav   +6 more
doaj   +1 more source

Measuring Nearby Star Forming Regions with the VLBA: from the Distance to the Dynamics [PDF]

arXiv, 2010
This thesis is part of a large ongoing effort to determine the distance and structure of all star-forming regions within several hundred parsecs of the Sun using radio-interferometric observations. The main goals of this thesis were: (1) Find the mean distance to the two best-studied nearby regions of low-mass star-formation (Taurus and Ophiuchus) with
arxiv