Results 121 to 130 of about 332,346 (345)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Large-scale Mapping Observations of DCN and DCO+ toward Orion KL

The Astrophysical Journal
We present emission maps ( $1\buildrel{\,\prime}\over{.} 5\,\times \,1\buildrel{\,\prime}\over{.} 5$ scale, corresponding to 0.18 pc) of the DCN ( J = 2 − 1) and DCO ^+ ( J = 2 − 1) lines in the 2 mm band toward the Orion KL region obtained with the 2 mm
Kotomi Taniguchi, Prathap Rayalacheruvu, Teppei Yonetsu, Tatsuya Takekoshi, Bunyo Hatsukade, Kotaro Kohno, Tai Oshima, Yoichi Tamura, Yuki Yoshimura, Víctor Gómez-Rivera, Sergio Rojas-García, Arturo I. Gómez-Ruiz, David H. Hughes, F. Peter Schloerb, Liton Majumdar, Masao Saito, Iván Rodríguez-Montoya, David Sánchez-Arguelles, Ryohei Kawabe   +18 more
doaj   +1 more source

Star-forming complexes in the polar ring galaxy NGC660

Open Astronomy, 2017
Galaxies with polar rings consist of two subsystems, a disk and a ring, which rotate almost in orthogonal planes. In this paper, we analyze the parameters characterizing the composition of the interstellar medium and star formation in star-forming ...
Smirnova Ksenia I., Wiebe Dmitri S., Moiseev Alexei V.   +2 more
doaj   +1 more source

Fundamental stellar parameters for selected T-Tauri stars in the Chamaeleon and Rho Ophiuchus star-forming regions [PDF]

, 2016
D. J. James, Alicia Aarnio, Alexander J. W. Richert, Phillip A. Cargile, N. C. Santos, C. Melo, J. Bouvier   +6 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Investigating the Influence of Radiative Feedback in the Bright-rimmed Cloud 44

The Astrophysical Journal
Radiative feedback from massive stars plays a central role in the evolution of molecular clouds and the interstellar medium. This paper presents a multiwavelength analysis of the bright-rimmed cloud (BRC) 44, which is located at the periphery of the H ii
Rishi C, Neelam Panwar, Thomas J. Haworth, Yan Sun, Saurabh Sharma, R. K. Yadav, D.K. Ojha, H.P. Singh, Jessy Jose, Ajay Kumar Singh, Jincen Jose, Shubham Yadav   +11 more
doaj   +1 more source

VLBI study of maser kinematics in high-mass star-forming regions [PDF]

, 2010
A. Sanna, L. Moscadelli, R. Cesaroni, A. Tarchi, Ray S. Furuya, C. Goddi   +5 more
openalex   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source