Results 121 to 130 of about 563,924 (339)

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Digging Into the Interior of Hot Cores with ALMA (DIHCA). V. Deuterium Fractionation of Methanol

The Astrophysical Journal
We have observed the ^13 CH _3 OH 5 _1 −4 _1 A ^+ , ^13 CH _3 OH 14 _1 −13 _2 A ^− , and CH _2 DOH 8 _2,6 −8 _1,7 e _0 lines toward 24 high-mass star-forming regions by using Atacama Large Millimeter/submillimeter Array with an angular resolution of ...
Takeshi Sakai, Nobuhito Shiomura, Patricio Sanhueza, Kenji Furuya, Fernando A. Olguin, Ken’ichi Tatematsu, Yuri Aikawa, Kotomi Taniguchi, Huei-Ru Vivien Chen, Kaho Morii, Fumitaka Nakamura, Shanghuo Li, Xing Lu, Qizhou Zhang, Tomoya Hirota, Kousuke Ishihara, Hongda Ke, Nami Sakai, Satoshi Yamamoto   +18 more
doaj   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Are There Age Spreads in Star Forming Regions? [PDF]

, 2011
To appear in the proceedings of JENAM10: Star Clusters in the Era of Large Surveys, 8 ...
openaire   +3 more sources

The dynamical evolution of star-forming regions measured with INDICATE [PDF]

arXiv
Observations of star-forming regions provide snapshots in time of the star formation process, and can be compared with simulation data to constrain the initial conditions of star formation. In order to make robust inferences, different metrics must be used to quantify the spatial and kinematic distributions of stars.
arxiv  

Distances to star forming regions [PDF]

arXiv, 2014
The determination of accurate distances to star-forming regions are discussed in the broader historical context of astronomical distance measurements. We summarize recent results for regions within 1 kpc and present perspectives for the near and more distance future.
arxiv  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Magnetic Field Alignment Relative to Multiple Tracers in the High-mass Star-forming Region RCW 36

The Astrophysical Journal
We use polarization data from SOFIA HAWC+ to investigate the interplay between magnetic fields and stellar feedback in altering gas dynamics within the high-mass star-forming region RCW 36, located in Vela C.
Akanksha Bij, Laura M. Fissel, Lars Bonne, Nicola Schneider, Marc Berthoud, Dennis Lee, Giles A. Novak, Sarah I. Sadavoy, Thushara G. S. Pillai, Maria Cunningham, Paul Jones, Robert Simon   +11 more
doaj   +1 more source

Nitrogen Sulfide (NS) in Star Forming Regions [PDF]

, 1992
D. McGonagle, William M. Irvine, Young Chol Minh   +2 more
openalex   +1 more source

The role of low-mass star clusters in massive star formation in Orion [PDF]

arXiv, 2013
To distinguish between the different theories proposed to explain massive star formation, it is crucial to establish the distribution, the extinction, and the density of low-mass stars in massive star-forming regions. We analyzed deep X-ray observations of the Orion massive star-forming region using the Chandra Orion Ultradeep Project (COUP) catalog ...
arxiv