Results 141 to 150 of about 1,621 (161)

Stargazin and the AMPA receptor

Science, 2016
Structural Biology AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking, gating, and pharmacology.
S. Hurtley
semanticscholar   +2 more sources

Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

Nature, 2000
Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate) receptors on cerebellar granule cells. Stargazin, the mutated protein, interacts with both AMPA receptor subunits and synaptic PDZ proteins, such as PSD-95.
Lu Chen, D. Chetkovich, R. Petralia, Neal T. Sweeney, Y. Kawasaki, R. Wenthold, D. Bredt, R. Nicoll   +7 more
semanticscholar   +3 more sources

Stargazin modulates AMPA receptor gating and trafficking by distinct domains

Nature, 2005
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors mediate fast excitatory synaptic transmission in the brain. These ion channels rapidly deactivate and desensitize, which determine the time course of synaptic transmission. Here, we find that the AMPA receptor interacting protein, stargazin, not only mediates AMPA receptor ...
S. Tomita, H. Adesnik, M. Sekiguchi, Wei Zhang, K. Wada, J. Howe, R. Nicoll, D. Bredt   +7 more
semanticscholar   +3 more sources

Stargazin modulates AMPA receptor antagonism

Neuropharmacology, 2008
AMPA receptors mediate the majority of fast synaptic transmission and underlie several forms of synaptic plasticity. AMPARs also have an important role in several neuronal pathologies. Therefore, studying the structure and function of these receptors is important for understanding general mechanisms of synaptic transmission as well as for the ...
Cokic, B., Stein, V.
openaire   +3 more sources

Stargazin Transports AMPA Receptors

Science Signaling, 2001
The murine stargazer phenotype is manifested by ataxia and epileptic seizures and is caused by mutations in the stargazin protein. Chen et al . describe the role of stargazin in the proper localization of AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole propionate) receptors but not NMDA ( N ...
openaire   +2 more sources

Stargazin interacts functionally with the AMPA receptor glutamate-binding module

Neuropharmacology, 2007
Neuronal AMPA receptors comprise pore forming glutamate receptor (GluR) proteins and auxiliary transmembrane AMPA receptor regulatory (TARP) subunits. TARPs traffic AMPA receptors to synapses and regulate channel gating. Both intracellular and extracellular regions in TARPs regulate AMPA receptors; however, the details for these interactions remain ...
Susumu, Tomita, Archana, Shenoy, Yuko, Fukata, Roger A, Nicoll, David S, Bredt   +4 more
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Stargazin involvement with bipolar disorder and response to lithium treatment

Pharmacogenetics and Genomics, 2008
Multiple reports have implicated chromosomal region 22q13.1 in both schizophrenia and bipolar disorder. The calcium channel gamma-2 subunit gene (cacng2, Stargazin) located on 22q13.1 was recently reported to be associated with schizophrenia. We aimed to examine the expression levels of Stargazin in post-mortem brain samples of patients with ...
Silberberg, G, Levit, A, Collier, D, Clair, D S, Munro, J, Kerwin, R W, Tondo, L, Floris, G, Breen, G, Navon, R   +9 more
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c-Fos, Arc, and Stargazin expression in rat eyeblink conditioning.

Behavioral Neuroscience, 2011
Neuronal plasticity induced by behavioral experience, as in memory formation, has been considered to involve transcriptional or translational changes in subsets of neurons involved in different forms of learning. Here, alteration in protein expression during cerebellar learning was investigated using rat eyeblink conditioning.
Soyun, Kim, Richard F, Thompson
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Differential localization and regulation of stargazin-like protein, γ-8 and stargazin in the plasma membrane of hippocampal and cortical neurons

Neuroscience Research, 2006
Transmembrane AMPA receptor regulatory proteins (TARPs), including stargazin/gamma-2, are associated with AMPA receptors and participate in their surface delivery and anchoring at the postsynaptic membrane. TARPs may also act as a positive modulator of the AMPA receptor ion channel function; however, little is known about other TARP members except for ...
Mihoko, Inamura, Makoto, Itakura, Hirotsugu, Okamoto, Sumio, Hoka, Akira, Mizoguchi, Yugo, Fukazawa, Ryuichi, Shigemoto, Saori, Yamamori, Masami, Takahashi   +8 more
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Stargazin, Traffic Cop and Gate Keeper

Science's STKE, 2005
Stargazin is best known for its role in trafficking AMPA-type glutamate receptors. Delivery of these cation channels to synapses in response to synaptic activity is one mechanism for increasing synaptic strength. Tomita et al. report that stargazin not only traffics AMPA receptors but also stays associated with the ...
openaire   +1 more source