Results 151 to 160 of about 2,605 (175)

A novel action of stargazin as an enhancer of AMPA receptor activity

Neuroscience Research, 2004
Stargazin (gamma-2) is disrupted in the ataxic and epileptic mutant mouse, stargazer (stg). The striking defect in the stg cerebellum is the lack of functional AMPA receptors on granule cells. Recently, it has been reported that gamma-2 and its related molecules are crucial for the surface expression, synaptic targeting and recycling of AMPA receptors,
Maya Yamazaki, Takako Ohno-Shosaku, Masahiro Fukaya   +2 more
exaly   +3 more sources

Stargazin interacts functionally with the AMPA receptor glutamate-binding module

Neuropharmacology, 2007
Neuronal AMPA receptors comprise pore forming glutamate receptor (GluR) proteins and auxiliary transmembrane AMPA receptor regulatory (TARP) subunits. TARPs traffic AMPA receptors to synapses and regulate channel gating. Both intracellular and extracellular regions in TARPs regulate AMPA receptors; however, the details for these interactions remain ...
Susumu Tomita, Yuko Fukata, Roger A Nicoll   +2 more
exaly   +3 more sources

Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs [PDF]

Neuron, 2005
Synaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA-type glutamate receptors at excitatory synapses; however, the crucial phosphorylated substrates remain uncertain. Here, we show that the AMPA receptor-associated protein stargazin is quantitatively phosphorylated and that stargazin phosphorylation promotes ...
Susumu Tomita, Valentin Stein, Roger A Nicoll   +2 more
exaly   +3 more sources

Stargazin modulates AMPA receptor gating and trafficking by distinct domains

Nature, 2005
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors mediate fast excitatory synaptic transmission in the brain. These ion channels rapidly deactivate and desensitize, which determine the time course of synaptic transmission. Here, we find that the AMPA receptor interacting protein, stargazin, not only mediates AMPA receptor ...
Susumu Tomita, Masayuki Sekiguchi, Wei Zhang   +2 more
exaly   +3 more sources

Learning from stargazin: the mouse, the phenotype and the unexpected

Current Opinion in Neurobiology, 2006
The stargazin gene (also referred to as Cacng2) has been identified by forward genetics in a spontaneous mouse mutant with ataxic gait, upward head-elevating movements (hence the name stargazer for the mouse) and episodes of spike-wave discharges. Stargazin is related to the gamma-1 subunit of skeletal muscle voltage-dependent calcium channel (VDCC ...
Osten, P., Stern-Bach, Y.
openaire   +3 more sources

Stargazin Transports AMPA Receptors

Science Signaling, 2001
The murine stargazer phenotype is manifested by ataxia and epileptic seizures and is caused by mutations in the stargazin protein. Chen et al . describe the role of stargazin in the proper localization of AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole propionate) receptors but not NMDA ( N ...
openaire   +2 more sources

Stargazin and the AMPA receptor

Science, 2016
Structural Biology AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking, gating, and pharmacology.
openaire   +1 more source

Differential localization and regulation of stargazin-like protein, γ-8 and stargazin in the plasma membrane of hippocampal and cortical neurons

Neuroscience Research, 2006
Transmembrane AMPA receptor regulatory proteins (TARPs), including stargazin/gamma-2, are associated with AMPA receptors and participate in their surface delivery and anchoring at the postsynaptic membrane. TARPs may also act as a positive modulator of the AMPA receptor ion channel function; however, little is known about other TARP members except for ...
Mihoko, Inamura, Makoto, Itakura, Hirotsugu, Okamoto, Sumio, Hoka, Akira, Mizoguchi, Yugo, Fukazawa, Ryuichi, Shigemoto, Saori, Yamamori, Masami, Takahashi   +8 more
openaire   +2 more sources

Stargazin involvement with bipolar disorder and response to lithium treatment

Pharmacogenetics and Genomics, 2008
Multiple reports have implicated chromosomal region 22q13.1 in both schizophrenia and bipolar disorder. The calcium channel gamma-2 subunit gene (cacng2, Stargazin) located on 22q13.1 was recently reported to be associated with schizophrenia. We aimed to examine the expression levels of Stargazin in post-mortem brain samples of patients with ...
Silberberg, G, Levit, A, Collier, D, Clair, D S, Munro, J, Kerwin, R W, Tondo, L, Floris, G, Breen, G, Navon, R   +9 more
openaire   +3 more sources

Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors [PDF]

Nature Neuroscience, 2007
Endogenous polyamines profoundly affect the activity of various ion channels, including that of calcium-permeable AMPA-type glutamate receptors (CP-AMPARs). Here we show that stargazin, a transmembrane AMPAR regulatory protein (TARP) known to influence transport, gating and desensitization of AMPARs, greatly reduces block of CP-AMPARs by intracellular ...
David Soto, Ian D Coombs, Mark Farrant
exaly   +3 more sources