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Stargazin differentially modulates ampakine gating kinetics and pharmacology
Biochemical Pharmacology, 2018It was previously reported that Stargazin (STG) enhances the surface expression of AMPA receptors, controls receptor gating and slows channel desensitization as an auxiliary subunit of the receptors. Ampakines are a class of AMPA receptor positive allosteric modulators that modify rates of transmitter binding, channel activity and desensitization ...
Daniel P, Radin +4 more
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Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Nature, 2000Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate) receptors on cerebellar granule cells. Stargazin, the mutated protein, interacts with both AMPA receptor subunits and synaptic PDZ proteins, such as PSD-95.
Lu Chen +2 more
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c-Fos, Arc, and Stargazin expression in rat eyeblink conditioning.
Behavioral Neuroscience, 2011Neuronal plasticity induced by behavioral experience, as in memory formation, has been considered to involve transcriptional or translational changes in subsets of neurons involved in different forms of learning. Here, alteration in protein expression during cerebellar learning was investigated using rat eyeblink conditioning.
Soyun, Kim, Richard F, Thompson
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Stargazin, Traffic Cop and Gate Keeper
Science's STKE, 2005Stargazin is best known for its role in trafficking AMPA-type glutamate receptors. Delivery of these cation channels to synapses in response to synaptic activity is one mechanism for increasing synaptic strength. Tomita et al. report that stargazin not only traffics AMPA receptors but also stays associated with the ...
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2006
Transmembrane AMPA Receptor Regulatory Proteins (TARPs) are the first transmembrane proteins known to associate with AMPA receptors. There are four known TARPs: γ-2, γ-3, γ-4, and γ-8. TARPs are expressed differentially in the brain but there is some overlap. Of these, γ-2, or stargazin is the most extensively studied.
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Transmembrane AMPA Receptor Regulatory Proteins (TARPs) are the first transmembrane proteins known to associate with AMPA receptors. There are four known TARPs: γ-2, γ-3, γ-4, and γ-8. TARPs are expressed differentially in the brain but there is some overlap. Of these, γ-2, or stargazin is the most extensively studied.
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Stargazin as a regulator of neuronal excitability
2023Neuronal excitability refers to the ability of neurons to generate a change in membrane voltage in response to stimuli, and it is a fundamental characteristic of neurons at the basis of neuronal communication. The M-current is a low-threshold potassium current that determines neuronal excitability and contributes to dampening repetitive neuronal firing.
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Dynamic Interaction of Stargazin-like TARPs with Cycling AMPA Receptors at Synapses
Science, 2004Activity-dependent plasticity in the brain arises in part from changes in the number of synaptic AMPA receptors. Synaptic trafficking of AMPA receptors is controlled by stargazin and homologous transmembrane AMPA receptor regulatory proteins (TARPs). We found that TARPs were stable at the plasma membrane, whereas AMPA receptors were internalized in a ...
Susumu, Tomita +3 more
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