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Inhibition of AMPA Receptors by Polyamine Toxins is Regulated by Agonist Efficacy and Stargazin

Neurochemical Research, 2014
The α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are glutamate-gated cation channels mediating the majority of fast excitatory synaptic transmission in the central nervous system (CNS). Polyamine toxins derived from spiders and wasps are use- and voltage-dependent channel blockers of Ca(2+)-permeable AMPARs.
Poulsen, Mette H, Lucas, Simon, Strømgaard, Kristian, Kristensen, Anders S   +3 more
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Stargazin Transports AMPA Receptors

Science's STKE, 2001
The murine stargazer phenotype is manifested by ataxia and epileptic seizures and is caused by mutations in the stargazin protein. Chen et al . describe the role of stargazin in the proper localization of AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole propionate) receptors but not NMDA ( N ...
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Stargazin and the AMPA receptor

Science, 2016
Structural Biology AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking, gating, and pharmacology.
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Differential localization and regulation of stargazin-like protein, γ-8 and stargazin in the plasma membrane of hippocampal and cortical neurons

Neuroscience Research, 2006
Transmembrane AMPA receptor regulatory proteins (TARPs), including stargazin/gamma-2, are associated with AMPA receptors and participate in their surface delivery and anchoring at the postsynaptic membrane. TARPs may also act as a positive modulator of the AMPA receptor ion channel function; however, little is known about other TARP members except for ...
Mihoko, Inamura, Makoto, Itakura, Hirotsugu, Okamoto, Sumio, Hoka, Akira, Mizoguchi, Yugo, Fukazawa, Ryuichi, Shigemoto, Saori, Yamamori, Masami, Takahashi   +8 more
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Glutamate Receptor Clusters: Narp, EphB2 Receptor, Stargazin

2009
M.C. Chang, R.W. Cho, P.F. Worley
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Stargazin differentially modulates ampakine gating kinetics and pharmacology

Biochemical Pharmacology, 2018
It was previously reported that Stargazin (STG) enhances the surface expression of AMPA receptors, controls receptor gating and slows channel desensitization as an auxiliary subunit of the receptors. Ampakines are a class of AMPA receptor positive allosteric modulators that modify rates of transmitter binding, channel activity and desensitization ...
Daniel P, Radin, Yong-Xin, Li, Gary, Rogers, Richard, Purcell, Arnold, Lippa   +4 more
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Stargazin, Traffic Cop and Gate Keeper

Science's STKE, 2005
Stargazin is best known for its role in trafficking AMPA-type glutamate receptors. Delivery of these cation channels to synapses in response to synaptic activity is one mechanism for increasing synaptic strength. Tomita et al. report that stargazin not only traffics AMPA receptors but also stays associated with the ...
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c-Fos, Arc, and Stargazin expression in rat eyeblink conditioning.

Behavioral Neuroscience, 2011
Neuronal plasticity induced by behavioral experience, as in memory formation, has been considered to involve transcriptional or translational changes in subsets of neurons involved in different forms of learning. Here, alteration in protein expression during cerebellar learning was investigated using rat eyeblink conditioning.
Soyun, Kim, Richard F, Thompson
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Stargazin as a regulator of neuronal excitability

2023
Neuronal excitability refers to the ability of neurons to generate a change in membrane voltage in response to stimuli, and it is a fundamental characteristic of neurons at the basis of neuronal communication. The M-current is a low-threshold potassium current that determines neuronal excitability and contributes to dampening repetitive neuronal firing.
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Dynamic Interaction of Stargazin-like TARPs with Cycling AMPA Receptors at Synapses

Science, 2004
Activity-dependent plasticity in the brain arises in part from changes in the number of synaptic AMPA receptors. Synaptic trafficking of AMPA receptors is controlled by stargazin and homologous transmembrane AMPA receptor regulatory proteins (TARPs). We found that TARPs were stable at the plasma membrane, whereas AMPA receptors were internalized in a ...
Susumu, Tomita, Masaki, Fukata, Roger A, Nicoll, David S, Bredt   +3 more
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