Results 141 to 150 of about 1,561 (160)

Stargazin interacts functionally with the AMPA receptor glutamate-binding module

Neuropharmacology, 2007
Neuronal AMPA receptors comprise pore forming glutamate receptor (GluR) proteins and auxiliary transmembrane AMPA receptor regulatory (TARP) subunits. TARPs traffic AMPA receptors to synapses and regulate channel gating. Both intracellular and extracellular regions in TARPs regulate AMPA receptors; however, the details for these interactions remain ...
Yuko Fukata, Susumu Tomita, Roger Nicoll
exaly   +3 more sources

Stargazin modulates AMPA receptor gating and trafficking by distinct domains

Nature, 2005
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors mediate fast excitatory synaptic transmission in the brain. These ion channels rapidly deactivate and desensitize, which determine the time course of synaptic transmission. Here, we find that the AMPA receptor interacting protein, stargazin, not only mediates AMPA receptor ...
Susumu Tomita, Roger Nicoll
exaly   +3 more sources

Stargazin Transports AMPA Receptors

Science's STKE, 2001
The murine stargazer phenotype is manifested by ataxia and epileptic seizures and is caused by mutations in the stargazin protein. Chen et al . describe the role of stargazin in the proper localization of AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole propionate) receptors but not NMDA ( N ...
openaire   +2 more sources

Stargazin and the AMPA receptor

Science, 2016
Structural Biology AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking, gating, and pharmacology.
openaire   +1 more source

Differential localization and regulation of stargazin-like protein, γ-8 and stargazin in the plasma membrane of hippocampal and cortical neurons

Neuroscience Research, 2006
Transmembrane AMPA receptor regulatory proteins (TARPs), including stargazin/gamma-2, are associated with AMPA receptors and participate in their surface delivery and anchoring at the postsynaptic membrane. TARPs may also act as a positive modulator of the AMPA receptor ion channel function; however, little is known about other TARP members except for ...
Mihoko, Inamura, Makoto, Itakura, Hirotsugu, Okamoto, Sumio, Hoka, Akira, Mizoguchi, Yugo, Fukazawa, Ryuichi, Shigemoto, Saori, Yamamori, Masami, Takahashi   +8 more
openaire   +2 more sources

Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors [PDF]

Nature Neuroscience, 2007
Endogenous polyamines profoundly affect the activity of various ion channels, including that of calcium-permeable AMPA-type glutamate receptors (CP-AMPARs). Here we show that stargazin, a transmembrane AMPAR regulatory protein (TARP) known to influence transport, gating and desensitization of AMPARs, greatly reduces block of CP-AMPARs by intracellular ...
David Soto, Stuart Cull-Candy, Mark Farrant   +2 more
exaly   +3 more sources

Stargazin differentially modulates ampakine gating kinetics and pharmacology

Biochemical Pharmacology, 2018
It was previously reported that Stargazin (STG) enhances the surface expression of AMPA receptors, controls receptor gating and slows channel desensitization as an auxiliary subunit of the receptors. Ampakines are a class of AMPA receptor positive allosteric modulators that modify rates of transmitter binding, channel activity and desensitization ...
Daniel P, Radin, Yong-Xin, Li, Gary, Rogers, Richard, Purcell, Arnold, Lippa   +4 more
exaly   +3 more sources

Stargazin, Traffic Cop and Gate Keeper

Science's STKE, 2005
Stargazin is best known for its role in trafficking AMPA-type glutamate receptors. Delivery of these cation channels to synapses in response to synaptic activity is one mechanism for increasing synaptic strength. Tomita et al. report that stargazin not only traffics AMPA receptors but also stays associated with the ...
openaire   +1 more source

c-Fos, Arc, and Stargazin expression in rat eyeblink conditioning.

Behavioral Neuroscience, 2011
Neuronal plasticity induced by behavioral experience, as in memory formation, has been considered to involve transcriptional or translational changes in subsets of neurons involved in different forms of learning. Here, alteration in protein expression during cerebellar learning was investigated using rat eyeblink conditioning.
Soyun, Kim, Richard F, Thompson
openaire   +2 more sources

Stargazin as a regulator of neuronal excitability

2023
Neuronal excitability refers to the ability of neurons to generate a change in membrane voltage in response to stimuli, and it is a fundamental characteristic of neurons at the basis of neuronal communication. The M-current is a low-threshold potassium current that determines neuronal excitability and contributes to dampening repetitive neuronal firing.
openaire   +1 more source