Results 201 to 210 of about 142,538 (255)

T-cell lymphoma-associated STAT3 variants impose a type 1 regulatory-like phenotype. [PDF]

Front Immunol
Schultz AB, Dalzell M, Nivelo L, Henrickson SE, Villarino AV.   +4 more
europepmc   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Inhibition of histone demethylase LSD1 suppresses CD47 expression and enhances efficacy of CD47 blockade in breast cancer. [PDF]

J Immunother Cancer
Jiang F, Shen Y, Li B, Henry M, Davidson N, Huang Y.   +5 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Targeting EHMT2 inhibition in glioblastoma: effects on tumor progression and STAT3 signaling. [PDF]

Transl Cancer Res
Xu C, Yin W, Zhang H, Zhang L.
europepmc   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

STAT Signaling and Its Anti-Apoptotic Effects in Dehydrated Xenopus laevis. [PDF]

Biol Cell
Biggar Y, Kamath AA, Breedon SA, Storey KB.   +3 more
europepmc   +1 more source

Overexpression of LINC00472 alleviates diabetic kidney disease progression via the miR-21-5p/STAT3 axis. [PDF]

Ren Fail
Sun P, Hu Y, Xu Z, Xiong F.
europepmc   +1 more source

Pharmacological inhibition of LIF signaling reverses PD-L1-mediated immune suppression in gastric cancer. [PDF]

Transl Oncol
Di Giorgio C, Marchianò S, Biagioli M, Lachi G, Massa C, Sensini B, Giannelli E, Sette MR, Urbani G, Paniconi F, Cari L, Monti MC, Sepe V, Natalizi N, Graziosi L, Distrutti E, Donini A, Zampella A, Fiorucci S.   +18 more
europepmc   +1 more source

Differentiation state affects PD-L1 expression in cutaneous melanoma: a systematic review. [PDF]

Cell Mol Biol Lett
Sævarsson T, Vu HN, Steingrímsson E, Einarsdóttir BÓ.   +3 more
europepmc   +1 more source