Results 211 to 220 of about 142,538 (255)
<i>SIX1</i> mediates pulmonary arterial hypertension endothelial dysfunction through the IL-6/STAT3 axis. [PDF]
J Thorac DisXiang HM, Wang Y, Xu Y, Sun JY, Guo Q.
europepmc +1 more source
Oncogenic cell fate decision in breast epithelial cells I: growth factors and mechanisms
Murali D, Gupta S, Subramaniam S.
europepmc +1 more source
Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA [PDF]
Journal of Biological Chemistry, 2012 Phosphorylation of signal transducer and activator of transcription 3 (STAT3) on a single tyrosine residue in response to growth factors, cytokines, interferons, and oncogenes activates its dimerization, translocation to the nucleus, binding to the interferon γ (gamma)-activated sequence (GAS) DNA-binding site and activation of transcription of target ...
Valeriy Korostyshevskiy +2 more
exaly +3 more sources
Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention [PDF]
Cancers, 2014 Signal Transducers and Activators of Transcription (STATs) are a family of transcription factors that regulate cell proliferation, differentiation, apoptosis, immune and inflammatory responses, and angiogenesis. Cumulative evidence has established that STAT3 has a critical role in the development of multiple cancer types.
Qiang Shen, Jia Zhou
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Targeting key transcriptional factor STAT3 in colorectal cancer
Molecular and Cellular Biochemistry, 2021In developed countries, colorectal cancer (CRC) is the fourth most common cancer and the second leading cause of malignant-related deaths. CRC is treatable cancer when diagnosed early; however, diagnosis at the advanced stage is associated with a poor prognosis. Although chemotherapy is generally very promising, STAT3 protein which is overexpressed and
Gayathri Chalikonda +3 more
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Role of STAT3 Transcription Factor in Pathogenesis of Bronchial Asthma
Biochemistry (Moscow), 2021Bronchial asthma is a heterogeneous chronic inflammatory disease of airways. The studies of molecular and cellular mechanisms of bronchial asthma have established that a wide range of immune (T and B cells, eosinophils, neutrophils, macrophages, etc.) and structural (epithelial and endothelial) cells are involved in its pathogenesis.
Aleksandr A, Nikolskii +5 more
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STAT3 transcription factor as target for anti-cancer therapy
Pharmacological Reports, 2020STATs constitute a large family of transcription activators and transducers of signals that have an important role in many cell functions as regulation of proliferation and differentiation of the cell also regulation of apoptosis and angiogenesis. STAT3 as a member of that family, recently was discovered to have a vital role in progression of different
Aliaa M. Mohassab +3 more
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Role of the Leukemia-associated Transcription Factor STAT3 in Platelet Physiology
Leukemia and Lymphoma, 2002Actinomycin D, a transcriptional inhibitor, was found to inhibit platelet potentiation by thrombopoietin (TPO), suggesting that TPO stimulation of platelets involves mitochondrial transcription. We sought to determine a possible role for leukemia-associated signal transducers and activators of transcription (STAT) proteins as mitochondrial ...
, Alexei Vassilev, Heather E Tibbles
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Implication of STAT1 and STAT3 transcription factors in the response to superantigens
Cytokine, 2004The activation of STAT1 and STAT3 in response to SEB was analyzed in spleen of Balb/c mice. The intraperitoneal injection of the superantigen SEB activated STAT1 and STAT3 in spleen. Activated STAT1 almost completely disappeared in 24 h even though activated STAT3 was present for more than 48 h after SEB injection.
R, Plaza +3 more
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