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Molecular Modulators of the Oncogenic Transcription Factor STAT3
2015Since the neoplastic phenotype of a cell is largely driven by aberrant gene expression patterns, increasing attention has been focused on transcription factors that regulate critical mediators of tumorigenesis such as signal transducer and activator of transcription 3 (STAT3). Here we investigate how the inappropriate activation of STAT3 contributes to
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STAT1 and STAT3 Transcription Factors in Inflammation-associated Colon Cancer
2012Inflammation is a strong promoter of colorectal cancer formation. Colorectal tumor cells establish heterotypic interactions with inflammatory cells in the stroma that are important for tumor angiogenesis and invasiveness. Recent studies in genetically modified mice have identified transcription factors and signaling networks that are implicated in ...
Paulina Rampetsreiter, Robert Eferl
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Cellular dynamics of the STAT3 transcription factor
Cytokine, 2009Velasco Cimica +2 more
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European Journal of Pharmacology
Constitutive activation of STAT3 plays important role in the pathogenesis of colorectal cancer (CRC). Inhibition of STAT3 has been proposed as a reasonable strategy to suppress CRC. Gamabufotalin (Gam), an effective bioactive compound of ChanChu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. However,
Nian Jiang +6 more
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Constitutive activation of STAT3 plays important role in the pathogenesis of colorectal cancer (CRC). Inhibition of STAT3 has been proposed as a reasonable strategy to suppress CRC. Gamabufotalin (Gam), an effective bioactive compound of ChanChu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. However,
Nian Jiang +6 more
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[The transcription factor STAT3 is associated with elements of the cytoskeleton in A-431 cells].
Tsitologiia, 1999The transcription factor STAT3 (signal transducers and activators of transcription) takes part in cell signaling. Here we show that STAT3 is associated with the cytoskeleton in A-431 cells. The protein is determined in cytoskeletal (detergent insoluble) fraction of control cells and of cells after RGF treatment.
A L, Evdonin +2 more
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Non‐canonical STAT3 function reduces REDD1 transcription
FEBS Journal, 2023Anna Dittrich, Fred Schaper
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Emerging role of signal transducer and activator of transcription 3 (STAT3) in pituitary adenomas
Endocrine Journal, 2021Toru Tateno +2 more
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STAT3: A critical transcription activator in angiogenesis
Medicinal Research Reviews, 2008Zhong Chao Han, Zhong Chen
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