Results 221 to 230 of about 833,114 (323)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

The EGR1–STAT3 Transcription Factor Axis Regulates α-Melanocyte–Stimulating Hormone–Induced Tyrosinase Gene Transcription in Melanocytes [PDF]

Journal of Investigative Dermatology, 2019
Soon Young Shin, Ji Hye Choi, Euitaek Jung, Ha-Na Gil, Yoongho Lim, Young Han Lee   +5 more
openaire   +2 more sources

Deciphering the STAT3-PXN positive feedback loop in GBM, IDH-wildtype: transcriptional regulation and inhibition of YB-1 ubiquitination. [PDF]

Cell Death Discov
Li X, Guo H, Liu Z, Wang T, Wang M, Chen W, Yu H.   +6 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities. [PDF]

Int J Oral Sci
Huang Z, Cui Y, Zhang W, Shen J, Dai Q, Sun S, Jiang L.   +6 more
europepmc   +1 more source

Peripheral Blood IL-6 and STAT3 Gene Expression as Biomarkers Associated with Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancer: A Prospective Cross-Sectional Study. [PDF]

Breast Cancer (Dove Med Press)
Özdemir K, Muhtaroğlu A, Kamburoğlu MB, Guney Eskiler G, Özman Gökçe Z, Kocer B.   +5 more
europepmc   +1 more source

CDK8 Inhibition Increases E2F1 Transcriptional Activity and Promotes STAT3-Dependent Suppression of Mcl-1 in Triple-Negative Breast Cancer Cell Line MDA-MB-468. [PDF]

Int J Mol Sci
Do S, Li S, Xiong R, Spear JM, Lu Z, Chan WK, Russu WA.   +6 more
europepmc   +1 more source

YWHAZ loss is associated with endometrial dysfunction in proliferative-phase endometriosis. [PDF]

Reproduction
Santos da Silva A, Rahman MS, Jeong EM, Nahar S, Young SL, Lessey BA, Jeong JW, Kim TH.   +7 more
europepmc   +1 more source

Oncogenic GPR161 Drives Melanoma Proliferation and Metabolic Activity through TXNIP Inhibition. [PDF]

J Microbiol Biotechnol
Roh Y, Choi J, Hwang JS, Lee YJ, Son T, Kim S, Gu N, Ban HS, Jung E, Kim JS, Han TS.   +10 more
europepmc   +1 more source