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Targeting transcription factor STAT3 for cancer prevention and therapy
Pharmacology & Therapeutics, 2016Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and ...
Lingzhi Wang +2 more
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STAT3 operates as a novel transcription factor that regulates NEDD4 in Keloid
Biochemical and Biophysical Research Communications, 2019Keloid, marked by excessive deposition of extracellular matrix components, usually occurs after cutaneous trauma. The molecular mechanism involved in the etiology of keloid remains largely unknown in spite of extensive studies presented on the mechanism of Keloid.
Liang Qiao
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The transcription factor STAT3 and aging: an intermediate medium
BiogerontologyAging is a physiological/pathological process accompanied by progressive impairment of cellular function, leading to a variety of aging-related diseases. STAT3 is one of the core regulatory factors of aging. It is involved in body metabolism, development and senescence, cell apoptosis and so on.
Min, Shi +4 more
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Transcription Factor STAT3 in Leptin Target Neurons of the Rat Hypothalamus
Neuroendocrinology, 1998Leptin is an adipose tissue-derived hormone that regulates body weight via interactions with hypothalamic neuronal circuitries expressing specific leptin receptors (Ob-R). The Ob-Rs act via the JAK-STAT (Janus kinase-signal transducers and activators of transcription) pathway of signal transduction.
M L, Håkansson, B, Meister
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Regulation and trafficking of the STAT3 transcription factor
2017The Signal Transducer and Activator of Transcription (STAT) family of transcription factors plays crucial roles in regulating important cellular responses via the regulation of target gene expression. Of the seven members of the STAT family, STAT3 has attracted considerable research interest due to its activation by a range of extracellular stimuli and
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STAT3 correlates with stem cell-related transcription factors in cervical cancer
Journal of Huazhong University of Science and Technology [Medical Sciences], 2015Cancer stem cells (CSCs) are considered responsible for the high recurrence rate in cervical carcinoma. It has been demonstrated that the signal transducer and activator of transcription 3 (STAT3) is involved in the oncogenesis and takes part in mediating the effects of maintaining stem cell phenotype and pluripotency by regulating the expression of ...
Hua, Wang +6 more
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Angiotensin II stimulates rapid serine phosphorylation of transcription factor Stat3
Molecular and Cellular Biochemistry, 1997In rat neonatal cardiac fibroblasts and CHO-K1 cells expressing angiotensin type 1 receptors, angiotensin II (AII) rapidly caused a time dependent reduction in the SDS-polyacrylamide gel electrophoretic mobility of Stat3 (Signal Transducer and Activator of Transcription).
G J, Bhat, K M, Baker
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Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy
Cancer Treatment Reviews, 2015Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many different types of cancer and plays a pivotal role in tumor growth and metastasis. Retrospective studies have established that STAT3 expression or phospho-STAT3 (pSTAT3 or activated STAT3) are poor prognostic markers for breast, colon, prostate and non-small ...
Joaquim Bosch-Barrera +1 more
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Transcription Factor STAT3 As a Prognostic Marker and Therapeutic Target in Cancer
Journal of Clinical Oncology, 2013In the early 1990s, researchers identified a mechanism by which cytokines interacting with cell surface receptors could modulate gene expression in the nucleus. Using elegant genetic and molecular approaches, it was found that activation of these receptors leads to phosphorylation of a family of proteins now called STATs that then shuttle into the ...
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The transcription factor Stat3 is dispensable for pancreatic β-cell development and function
Biochemical and Biophysical Research Communications, 2005The transcription factor Stat3 is activated by multiple cytokines, including leptin and those signaling through the gp130 receptor. In two independent studies, mice in which the Stat3 gene was inactivated using a RIP-Cre transgene led to glucose intolerance, defects in early-phase insulin secretion, and mild obesity [S. Gorogawa, Y. Fujitani, H. Kaneto,
Ji-Yeon, Lee, Lothar, Hennighausen
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