Results 1 to 10 of about 34,891 (226)
STAT5-Interacting Proteins: A Synopsis of Proteins that Regulate STAT5 Activity [PDF]
Biology, 2017 Signal Transducers and Activators of Transcription (STATs) are key components of the JAK/STAT pathway. Of the seven STATs, STAT5A and STAT5B are of particular interest for their critical roles in cellular differentiation, adipogenesis, oncogenesis, and ...
Ashley A. Able +2 more
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Involvement of STAT5 in Oncogenesis [PDF]
Biomedicines, 2020 Signal transducer and activator of transcription (STAT) proteins, and in particular STAT3, have been established as heavily implicated in cancer. Recently, the involvement of STAT5 signalling in the pathology of cancer has been shown to be of increasing ...
Clarissa Esmeralda Halim +3 more
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Analysis of Potential Non-Canonical or Alternate STAT5 Functions in Immune Development and Growth
Frontiers in Bioscience-Landmark, 2023 Background: Signal transducer and activator of transcription (STAT) proteins play key roles in development, growth, and homeostasis. These roles have principally been assigned to their “canonical” function as inducible transcriptional activators acting ...
Nagendra Awasthi +2 more
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Frontiers in Neurology, 2021 The HIV-1 pandemic is a significant challenge to the field of medicine. Despite advancements in antiretroviral (ART) development, 38 million people worldwide still live with this disease without a cure.
Angel Lin +10 more
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Архивъ внутренней медицины, 2022 The aim of the investigation was to study the relationship between the content of whole blood in mononuclear leukocytes in pneumonia and in apparently healthy individuals of cytokine signaling suppressor 2 (SOCS2) with the production of cytokines (TNFα ...
S. S. Bondar +4 more
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Platelets, 2022 Several Janus kinase (JAK) inhibitors (jakinibs) have recently been approved to treat inflammatory, autoimmune and hematological conditions. Despite emerging roles for JAKs and downstream signal transducer and activator of transcription (STAT) proteins ...
Iván Parra-Izquierdo +9 more
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CTLA‐4 interacts with STAT5 and inhibits STAT5‐mediated transcription [PDF]
Immunology, 2006 SummaryCytotoxic T‐lymphocyte antigen‐4 (CTLA‐4; CD152) is a member of the immunoglobulin gene superfamily with strong homology to the receptor CD28 with which it shares the ligands CD80 and CD86. Unlike CD28, a potent costimulator of T‐cell responses, CTLA‐4 is transiently expressed on the cell surface of activated T cells and appears to operate ...
Srahna, M +3 more
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The different functions of Stat5 and chromatin alteration through Stat5 proteins [PDF]
Frontiers in Bioscience, 2008 Stat5 proteins modulate gene transcription upon cytokine- and growth factor action. Stat5a and Stat5b proteins alone are weak activators of transcription. They can modify chromatin organization through oligomerization and they act predominantly in co-operation and interaction with other proteins.
Kornfeld, Jan-Wilhelm +14 more
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Differential cytokine sensitivities of STAT5-dependent enhancers rely onStat5autoregulation [PDF]
Nucleic Acids Research, 2016 Cytokines utilize the transcription factor STAT5 to control cell-specific genes at a larger scale than universal genes, with a mechanistic explanation yet to be supplied. Genome-wide studies have identified putative STAT5-based mammary-specific and universal enhancers, an opportunity to investigate mechanisms underlying their differential response to ...
Willi, Michaela +4 more
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Characterization of the Stat5 Protease [PDF]
Journal of Biological Chemistry, 1999 Immature myeloid cells have been shown to transduce signals through a carboxyl-terminally truncated isoform of Stat5. This functionally distinct signal transducer and activator of transcription isoform is generated through a unique protein-processing event.
C, Lee +7 more
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