Results 91 to 100 of about 34,891 (226)

Epidermal growth factor stimulates STAT5 via EGFR to promote lung adenocarcinoma growth

Egyptian Journal of Medical Human Genetics
Background/aim Activation of the epidermal growth factor receptor (EGFR) by its ligand, epidermal growth factor (EGF), initiates multiple signaling cascades that enhance tumor cell growth and survival.
Dian Jamel Salih, Khesar Hussein Khalil, Saraa Hanna Barsoom, Narmeen Adalat Hasan, Nicoletta Pia Ardò, Domenico Loizzi   +5 more
doaj   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Regulation of STAT5 phosphorylation and interaction with SHP1 by lnc-AC004893, a long non-coding RNA overexpressed in myeloproliferative neoplasms

Hematology
Objectives Constitutive activation of Janus kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway is central to the pathogenesis of myeloproliferative neoplasms (MPNs).
Junjun Yang, Jichen Ruan, Bin Zhou, Sisi Ye, Shenmeng Gao, Xiaoqun Zheng   +5 more
doaj   +1 more source

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, EarlyView.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells.

PLoS ONE, 2014
Signal transducers and activators of transcription 5(STAT5) are cytokine induced signaling proteins, which regulate key immunological processes, such as tolerance induction, maintenance of homeostasis, and CD4 T-effector cell differentiation.
Aradhana Rani, Aradhana Rani, Roseanna Greenlaw, Manohursingh Runglall, Stipo Jurcevic, Susan John   +5 more
doaj   +1 more source

IL‐2 silencing enables Tfh cell expansion during vaccination but is redundant for antibody production

Immunology &Cell Biology, EarlyView.
Sustained IL‐2 production delays T follicular helper cell differentiation and germinal center formation but does not alter final antibody titers or antigen‐specific humoral immunity after vaccination. Created in BioRender. Burton, A. (2026) https://BioRender.com/paggz41 Abstract Vaccines stimulate protective humoral immunity by coordinating lymphocyte ...
Silvia Innocentin, Ross McKenzie, Jayalini Assalaarachchi, Helena A Carslaw, Anusha Gupta, Sanne Cole, Adrian Liston, Michelle A Linterman, Louise Webb, Alice R Burton   +9 more
wiley   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Protective Role of the Podocyte IL-15 / STAT5 Pathway in Focal Segmental Glomerulosclerosis

Kidney International Reports
Introduction: During glomerular diseases, podocyte-specific pathways can modulate the intensity of histological disease and prognosis. The therapeutic targeting of these pathways could thus improve the management and prognosis of kidney diseases.
Aïssata Niasse, Kevin Louis, Olivia Lenoir, Chloé Schwarz, Xiaoli Xu, Aymeric Couturier, Hélène Dobosziewicz, Anthony Corchia, Sandrine Placier, Sophie Vandermeersch, Lothar Hennighausen, Perrine Frère, Pierre Galichon, Brigitte Surin, Souhila Ouchelouche, Liliane Louedec, Tiffany Migeon, Marie-Christine Verpont, Nadir Yousfi, David Buob, Yi-Chun Xu-Dubois, Hélène François, Eric Rondeau, Laurent Mesnard, Juliette Hadchouel, Yosu Luque   +25 more
doaj   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source