Results 111 to 120 of about 34,891 (226)

The spleen–brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Emerging evidence highlights the central role of peripheral immune–metabolic regulation in the pathogenesis of Alzheimer's disease and related dementias (ADRD). Among peripheral organs, the spleen has gained increasing attention as a critical immune–metabolic hub linking systemic homeostasis to central neurodegeneration.
Jingsi Yan, Jiayu Zhang, Xinyi Ye, Huihong Wang, Hang Li, Weirong Li, Huifei Wu, Wei Zhao   +7 more
wiley   +1 more source

E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 signaling pathway by facilitating K27-linked polyubiquitination of IL-3Rα

Cell Communication and Signaling
IL-3/STAT5 signaling pathway is crucial for the development and activation of immune cells, contributing to the cellular response to infections and inflammatory stimuli. Dysregulation of the IL-3/STAT5 signaling have been associated with inflammatory and
Jingge Yu, Jianguo Li, Ao Shen, Zhiping Liu, Tian-Sheng He   +4 more
doaj   +1 more source

Successful Treatment of Primary Poor Graft Function After Haploidentical Hematopoietic Stem Cell Transplantation With Low‐Dose Decitabine Followed by Donor Lymphocyte Infusion and Eltrombopag

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Objective Primary poor graft function (PGF) is a common and serious complication after haploidentical hematopoietic stem cell transplantation (haplo‐HSCT). This study retrospectively evaluates the efficacy and safety of a novel combination therapy consisting of low‐dose decitabine, donor lymphocyte infusion (DLI), and eltrombopag for the ...
Jiaojiao Yuan, Junjie Cao, Peipei Ye, Tiantian Wang, Dong Chen, Shuangyue Li, Renzhi Pei, Juntao Zhang, Ying Lu   +8 more
wiley   +1 more source

Enhanced PIEZO1 expression in mast cells of mastocytosis skin lesions: Relevance to Darier's sign

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Yoshiaki Kobayashi, Nobuhiro Nakano, Nguyen Quoc Vuong Tran, Yuki Nakamura, Lisa Minai, Takashi Okamoto, Daiki Nakagomi, Tatsuki R. Kataoka, Tatsuyoshi Kawamura, Atsuhito Nakao   +9 more
wiley   +1 more source

Bone Marrow Involvement in Sarcoidosis: A Case Report of Granulomatous and Hematologic Complications

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Bone marrow involvement in sarcoidosis is rare and poorly understood. This case highlights the hematologic complexity of sarcoidosis, including its association with aplastic anemia and T‐cell large granular lymphocytic leukemia (T‐LGLL). We report a 70‐year‐old male with longstanding sarcoidosis who developed multiple hematologic complications,
Nina Couette, Zachary Braunstein, Daniel Jones, Jonathan E. Brammer, Arindam Singha   +4 more
wiley   +1 more source

Adiponectin Participates in Preeclampsia by Regulating the Biological Function of Placental Trophoblasts through P38 MAPK-STAT5 Pathway

Iranian Journal of Public Health, 2018
Background: We aimed to investigate the participation of adiponectin in preeclampsia, and to explore the possible mechanism. Methods: A total of 52 patients with preeclampsia and 30 normal women with full-term pregnancy were enrolled ...
Gaoxia DONG, Ying TIAN, Xinqin LI
doaj  

A Link Between Allergy and Hematological Malignancies? Focus on Possible Mechanisms and the Potential Role of Biological Therapies

Clinical and Translational Allergy, Volume 16, Issue 3, March 2026.
ABSTRACT Immune dysregulation has been widely recognized in the international literature as an underlying condition for hematological malignancies and allergic disorders. This commonality has led researchers to study the potential association, positive or negative, between blood cancers and allergy, but the results remain unclear.
Stefania Isola, Luca Gammeri, Federica Nuccio, Alessandro Allegra, Giorgio Walter Canonica, Sebastiano Gangemi   +5 more
wiley   +1 more source

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito, Paula Sabbo Bernardo, Jean‐Edouard Martin, Caroline Marty, Isabelle Plo, Iléana Antony‐Debré, Bárbara da Costa Reis Monte‐Mór   +6 more
wiley   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Tumor‐infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors

International Journal of Cancer, Volume 158, Issue 5, Page 1156-1165, 1 March 2026.
Abstract Tumor‐infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti‐tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B cells (Bregs) and immunosuppressive plasma cells—contribute to immune evasion by secreting inhibitory ...
Zhitong Li, Ziyang Shen, Yuxiang Sun, Pengcheng Zhu, Tongyan Liu, Rong Yin   +5 more
wiley   +1 more source