Results 121 to 130 of about 34,891 (226)

Successful Treatment of Paediatric Necrobiosis Lipoidica With Baricitinib

JEADV Clinical Practice, Volume 5, Issue 1, Page 246-249, March 2026.
ABSTRACT Necrobiosis lipoidica (NL) is a rare, chronic granulomatous condition that typically presents as sharply demarcated plaques with telangiectasia and atrophic centres. Paediatric cases are uncommon, and treatment options often fail to address refractory cases.
P. Simões Farinha, M. J. Paiva‐Lopes
wiley   +1 more source

Radiosensitized by STAT5 blockade [PDF]

Nature Reviews Urology, 2018
openaire   +1 more source

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang, Qianyu Hu, Caiqin Wang, Yizi He, Ruolan Zeng, Yajun Li, Chang Su, Guige Lu, Xueting Zhu, Ling Xiao, Hui Zhou   +10 more
wiley   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

T‐Cell Signaling Pathways, Including Exhaustion, Predominate in Unhealthy Visceral and Subcutaneous Adipose Tissues

Obesity, Volume 34, Issue 3, Page 674-685, March 2026.
ABSTRACT Objective Obesity is an imperfect correlate of metabolic health. Visceral adipose tissue (VAT) characteristics are considered determinants of poor health and subcutaneous adipose tissue (SAT) considered protective. There is a gap in knowledge regarding shared vs.
Sobha Puppala, Alyssa R. Hamann, Christina M. Stevens, Alistaire Ruggiero, Laura A. Cox, Kylie Kavanagh   +5 more
wiley   +1 more source

Insights Into Macrophage Polarization and M1/M2 Balance in Diabetic Foot Ulcers

Journal of Diabetes, Volume 18, Issue 3, March 2026.
This graphical abstract illustrates pharmaceutical agents that modulate M1/M2 macrophage polarization in diabetic foot ulcers (DFUs). M1 macrophages (red) drive inflammation, whereas M2 macrophages (blue) promote tissue repair. In DFUs, persistent M1 predominance contributes to chronic non‐healing. Five key agents targeting this imbalance are depicted:
Jing Zhang, Hong Li, Yulin Dong, Zhuoyan Zhou, Yuhan Wang, Xia Chen, Yulan Cai   +6 more
wiley   +1 more source

Selective Janus kinase inhibitors exhibit different effects in murine immune aplastic anemia

HemaSphere, Volume 10, Issue 3, March 2026.
Jibran Durrani, Xingmin Feng, Zhijie Wu, Shouguo Gao, Ash Lee Manley, Liangliang Wu, Joshua Glass, Bhavisha A. Patel, Jichun Chen, Neal S. Young, Emma M. Groarke   +10 more
wiley   +1 more source

The Immune Cell Atlas of “Longevity Molecular Tag”: Identification of Principal Immune Cell Subsets and Their Underlying Molecular Regulatory Mechanisms

Aging Cell, Volume 25, Issue 3, March 2026.
This study aims to develop an immune cell atlas of the “Longevity Molecular Tags” by employing the Scissor algorithm to identify key immune cell subsets associated with longevity phenotypes. Subsequently, the underlying immune molecular mechanisms contributing to the longevity‐associated immune cell subsets were investigated through differential gene ...
Zhiling Zhang, Huabin Su, Shihui Fu, Fansen Ji, Liuguan Liang, Wanlu Song, Caiyou Hu, Liuxiang Wei, Erping Long, Yang Lin, Xiaolin Ni   +10 more
wiley   +1 more source

The antitumor mechanism of oclacitinib in canine lymphoma. [PDF]

Sci Rep
Harada M, Inanaga S, Sakurai M, Shibutani S, Sugasawa T, Murayama N, Osumi T, Baba Y, Sakai H, Maeda S, Igase M, Mizuno T.   +11 more
europepmc   +1 more source