Results 11 to 20 of about 34,891 (226)
Benzodiazepines Drive Alteration of Chromatin at the Integrated HIV-1 LTR
Viruses, 2020 Antiretroviral therapy (ART) lowers human immunodeficiency virus type 1 (HIV-1) viral load to undetectable levels, but does not eliminate the latent reservoir.
Weam Elbezanti +8 more
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Translational Oncology, 2022 Signal transducer and activator of transcription 5 (STAT5) signaling plays a pathogenic role in both hematologic malignancies and solid tumors. In acute myeloid leukemia (AML), internal tandem duplications of fms-like tyrosine kinase 3 (FLT3-ITD ...
Anna J. Dellomo +6 more
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Maximal STAT5-Induced Proliferation and Self-Renewal at Intermediate STAT5 Activity Levels [PDF]
Molecular and Cellular Biology, 2008 The level of transcription factor activity critically regulates cell fate decisions, such as hematopoietic stem cell (HSC) self-renewal and differentiation. We introduced STAT5A transcriptional activity into human HSCs/progenitor cells in a dose-dependent manner by overexpression of a tamoxifen-inducible STAT5A(1*6)-estrogen receptor fusion protein ...
Wierenga, Albertus T. J. +2 more
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Haematologica, 2022 Physiological and pathogenic interleukin-7-receptor (IL7R)-induced signaling provokes glucocorticoid resistance in a subset of patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL).
Jordy C.G. van der Zwet +10 more
doaj +1 more source
Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia [PDF]
Cancer Research, 2018 Abstract Combining standard cytotoxic chemotherapy with BCR-ABL1 tyrosine kinase inhibitors (TKI) has greatly improved the upfront treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL).
Minieri, Valentina +9 more
openaire +3 more sources
STAT5 and CD4+ T Cell Immunity [PDF]
F1000Research, 2017 STAT5 plays a critical role in the development and function of many cell types. Here, we review the role of STAT5 in the development of T lymphocytes in the thymus and its subsequent role in the differentiation of distinct CD4+helper and regulatory T-cell subsets.
Owen, David L., Farrar, Michael A.
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Ikaros antagonizes DNA binding by STAT5 in pre-B cells.
PLoS ONE, 2020 The IKZF1 gene, which encodes the Ikaros transcription factor, is frequently deleted or mutated in patients with B-cell precursor acute lymphoblastic leukemias that express oncogenes, like BCR-ABL, which activate the JAK-STAT5 pathway.
Beate Heizmann +5 more
doaj +1 more source
Autoimmunity, 2020 Background: CXCL4 plays an essential role in the regulation of multiple immune diseases. However, the underlying role of CXCL4 is still not clear in sepsis. Aim: In the present study, we aimed to investigate the function of CXCL4 in sepsis.
Tao Xu +8 more
doaj +1 more source
Identification of a STAT5 target gene, Dpf3, provides novel insights in chronic lymphocytic leukemia. [PDF]
PLoS ONE, 2013 STAT5 controls essential cellular functions and is encoded by two genes, Stat5a and Stat5b. To provide insight to the mechanisms linking hematologic malignancy to STAT5 activation/regulation of target genes, we identified STAT5 target genes and focused ...
Marina Theodorou +6 more
doaj +1 more source
CPAP Is a Novel Stat5-Interacting Cofactor that Augments Stat5-Mediated Transcriptional Activity [PDF]
Molecular Endocrinology, 2002 Stat5, a member of the signal transducer and activators of transcription (Stat) protein family, is a primary mediator of prolactin (PRL) signaling in the mammary gland. There are two distinct Stat5 genes, Stat5a and Stat5b. The Stat5a isoform has been demonstrated to have an essential role in mammary epithelial differentiation, whereas Stat5b is ...
Benjamin, Peng +7 more
openaire +2 more sources