Results 191 to 200 of about 34,891 (226)
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STAT5 activity in pancreatic β-cells
Expert Review of Endocrinology & Metabolism, 2008Signal transducer and activator of transcription (STAT)5A and -5B are latent transcription factors activated by cytokines and hormones of the cytokine family. In pancreatic insulin-secreting β-cells, STAT5A and -5B are activated primarily by prolactin and growth hormone stimulation and are important mediators of the potent stimulation of proliferation ...
Louise T, Dalgaard +2 more
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Brain STAT5 signaling and behavioral control
Molecular and Cellular Endocrinology, 2016Several growth factors and cytokines recruit the signal transducer and activator of transcription 5 (STAT5) signaling pathway to control cell proliferation, differentiation and apoptosis. Nonetheless, the importance of this transcription factor for brain functions is still poorly understood.
Isadora C, Furigo +3 more
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Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation
Proceedings of the National Academy of Sciences, 2021Significance Multiple sclerosis (MS) is an immune-mediated disease that impacts the central nervous system. A murine model of MS, experimental autoimmune encephalomyelitis (EAE), is used to determine the mechanism of MS pathogenesis. STAT5 is a transcription factor that plays a critical role in mediating cellular responses following cytokine ...
Kelly L. Monaghan +13 more
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STAT5 contributes to antiapoptosis in melanoma
Melanoma Research, 2008Malignant melanoma is a cancer whose incidence is rising rapidly. Extensive studies of primary tumors and tumor-derived cell lines revealed that inappropriate activation of signal transducer and activator of transcription (STAT) proteins, particularly of STAT3 and 5, occurs with high frequency in various human cancers.
Hassel, Jessica C. +3 more
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An SH2 domain model of STAT5 in complex with phospho-peptides define “STAT5 Binding Signatures”
Journal of Computer-Aided Molecular Design, 2015The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT activation is regulated by phosphorylation of protein monomers at conserved tyrosine residues, followed by binding to phospho-peptide pockets and subsequent dimerization.
Eleonora, Gianti, Randy J, Zauhar
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GASing up iron delivery via STAT5
Blood, 2008Ramping up and maintaining a high rate of iron delivery to support heme biosynthesis is both unique and fundamental to erythroid maturation. In this issue, Zhu and colleagues reveal a previously unappreciated role of the cytokine-activated transcription factor STAT5A/B as a regulator of ...
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Coactivators in Gene Regulation by STAT5
2005Signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of transcription factors that relay the effect of diverse cytokines, hormones, and growth factors by regulating the transcription of distinct target genes.
Claudia M, Litterst +3 more
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STAT5 in B cell development and leukemia
Current Opinion in Immunology, 2010Early B cell development depends on a network of transcription factors, whereby E2A and EBF1 regulate B cell specification and Pax5 controls B-lineage commitment. In contrast, activation of the transcription factor STAT5 in response to IL-7R signaling promotes cell survival by activating the prosurvival gene Mcl1 and orders immunoglobulin gene ...
Stephen, Malin +2 more
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IL-6 activates STAT5 in T cells
Cytokine, 2012IL-6 is a pleiotropic cytokine which emerged recently as a key regulator of CD4 T cell function. IL-6 alone or in combination with other cytokines promotes T helper 1, T helper 17 and T follicular helper cell differentiation whilst inhibiting the induction of regulatory T cell generation.
Aurélie Jeanne, Tormo +5 more
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Inhibitors of Stat5 protein signalling
Med. Chem. Commun., 2012Evidence shows that signal transducer and activator of transcription 5 (Stat5) protein, a member of the STAT family of signalling proteins, plays a pivotal role in the progression of many human cancers including acute myeloid leukemias and prostate cancer.
Abbarna A. Cumaraswamy +4 more
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