Results 201 to 210 of about 34,891 (226)
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STAT5 controls Tfh development (121.19)
The Journal of Immunology, 2012Abstract Recent work has identified a new subset of CD4+ T cells named as T follicular helper (Tfh) cells that are localized in germinal centers and critical in germinal-center formation. Tfh cell differentiation is regulated by IL-6 and IL-21, possibly via STAT3 factor, and Bcl6 is specifically expressed in Tfh cells and required for ...
Roza Nurieva +6 more
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Blood, 2004
Abstract Fanconi anemia (FA) cells are hypersensitive to oxidative stress and exhibit aberrant STAT activation responses to defined extracellular proteins but whether these abnormalities are linked is unclear. Because oxidative stress is known to induce STAT activation, we hypothesized that proper STAT signaling responses in normal cells
Grover Bagby +6 more
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Abstract Fanconi anemia (FA) cells are hypersensitive to oxidative stress and exhibit aberrant STAT activation responses to defined extracellular proteins but whether these abnormalities are linked is unclear. Because oxidative stress is known to induce STAT activation, we hypothesized that proper STAT signaling responses in normal cells
Grover Bagby +6 more
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STAT5 signaling in normal and pathologic hematopoiesis
Frontiers in Bioscience, 2007Hematopoietic development is highly dependent upon cytokine/receptor initiated signaling pathways. Of those activated in hematopoietic cells, the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway plays a major role.
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The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity
Nature Immunology, 2021Jiajia Zhou, Ilona Kryczek, Xiong Li
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