Results 21 to 30 of about 34,891 (226)

The natural chemopreventive agent sulforaphane inhibits STAT5 activity. [PDF]

PLoS ONE, 2014
Signal transducer and activator of transcription STAT5 is an essential mediator of cytokine, growth factor and hormone signaling. While its activity is tightly regulated in normal cells, its constitutive activation directly contributes to oncogenesis and
Sophia Pinz, Samy Unser, Anne Rascle
doaj   +1 more source

STAT3 but Not STAT5 Contributes to the Protective Effect of Electroacupuncture Against Myocardial Ischemia/Reperfusion Injury in Mice

Frontiers in Medicine, 2021
Electroacupuncture (EA) can help reduce infarct size and injury resulting from myocardial ischemia/reperfusion (I/R); however, the underlying molecular mechanism remains unknown.
Hui-Hui Guo, Xin-Yue Jing, Hui Chen, Hou-Xi Xu, Bing-Mei Zhu   +4 more
doaj   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

STAT5 is activated in macrophages by breast cancer cell-derived factors and regulates macrophage function in the tumor microenvironment

Breast Cancer Research, 2021
Background In breast cancer, complex interactions between tumor cells and cells within the surrounding stroma, such as macrophages, are critical for tumor growth, progression, and therapeutic response.
Emily A. Jesser, Nicholas J. Brady, Danielle N. Huggins, Patrice M. Witschen, Christine H. O’Connor, Kathryn L. Schwertfeger   +5 more
doaj   +1 more source

Glucocorticoid Receptor/Signal Transducer and Activator of Transcription 5 (STAT5) Interactions Enhance STAT5 Activation by Prolonging STAT5 DNA Binding and Tyrosine Phosphorylation [PDF]

Molecular Endocrinology, 1999
The regulation of casein gene expression by both PRL and glucocorticoids has been a well studied paradigm for understanding how the signaling pathways regulated by these two hormones interact in the nucleus. Previous studies have demonstrated that the downstream effectors of these pathways, signal transducer and activator of transcription 5 (STAT5) and
S L, Wyszomierski, J, Yeh, J M, Rosen
openaire   +3 more sources

Activated STAT5 Confers Resistance to Intestinal Injury by Increasing Intestinal Stem Cell Proliferation and Regeneration

Stem Cell Reports, 2015
Intestinal epithelial stem cells (IESCs) control the intestinal homeostatic response to inflammation and regeneration. The underlying mechanisms are unclear. Cytokine-STAT5 signaling regulates intestinal epithelial homeostasis and responses to injury. We
Shila Gilbert, Harini Nivarthi, Christopher N. Mayhew, Yuan-Hung Lo, Taeko K. Noah, Jefferson Vallance, Thomas Rülicke, Mathias Müller, Anil G. Jegga, Wenjuan Tang, Dongsheng Zhang, Michael Helmrath, Noah Shroyer, Richard Moriggl, Xiaonan Han   +14 more
doaj   +1 more source

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung. [PDF]

PLoS ONE, 2013
The Signal Transducer and Activator of Transcription 5 (Stat5) plays a significant role in normal hematopoiesis and a variety of hematopoietic malignancies.
Wan-chi Lin, Jeffrey W Schmidt, Bradley A Creamer, Aleata A Triplett, Kay-uwe Wagner   +4 more
doaj   +1 more source

The decoy oligodeoxynucleotide against HIF-1α and STAT5 ameliorates atopic dermatitis-like mouse model

Molecular Therapy: Nucleic Acids, 2023
Atopic dermatitis (AD) is a common inflammatory skin disease caused by an immune disorder. Mast cells are known to be activated and granulated to maintain an allergic reaction, including rhinitis, asthma, and AD. Although hypoxia-inducible factor-1 alpha
Mi-Gyeong Gwon, Jaechan Leem, Hyun-Jin An, Hyemin Gu, Seongjae Bae, Jong Hyun Kim, Kwan-Kyu Park   +6 more
doaj   +1 more source

STAT5 is an ambivalent regulator of neutrophil homeostasis. [PDF]

PLoS ONE, 2007
BACKGROUND: Although STAT5 promotes survival of hematopoietic progenitors, STAT5-/- mice develop mild neutrophilia. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that in STAT5-/- mice, liver endothelial cells (LECs) autonomously secrete high amounts of G-
Laurence Fiévez, Christophe Desmet, Emmanuelle Henry, Bernard Pajak, Silke Hegenbarth, Virginie Garzé, Françoise Bex, Fabrice Jaspar, Philippe Boutet, Laurent Gillet, Alain Vanderplasschen, Percy A Knolle, Oberdan Leo, Muriel Moser, Pierre Lekeux, Fabrice Bureau   +15 more
doaj   +1 more source

Identification of a Novel, Oncogenic and Targetable <i>TPR::ABL2</i> Fusion Gene in T-Cell Acute Lymphoblastic Leukaemia. [PDF]

EJHaem
ABSTRACT ABL2 rearrangements represent a subtype of acute lymphoblastic leukaemia (ALL) associated with poor prognosis and survival. This study reports a high‐risk T‐cell ALL (T‐ALL) case with a novel TPR::ABL2 gene fusion resulting from a chromosomal deletion.
Lagonik E, Page EC, Eadie LN, Schutz CE, Rehn JA, Heatley SL, Moore AS, Healy M, Whyte M, Hughes TP, Yeung DT, White DL.   +11 more
europepmc   +2 more sources