Results 31 to 40 of about 34,891 (226)
Journal of Interferon & Cytokine Research, 2016 Signal transducers and activators of transcription 5 (STAT5a and STAT5b) are highly homologous proteins that are encoded by 2 separate genes and are activated by Janus-activated kinases (JAK) downstream of cytokine receptors. STAT5 proteins are activated by a wide variety of hematopoietic and nonhematopoietic cytokines and growth factors, all of which ...
Rani, Aradhana, Murphy, John
openaire +4 more sources
Cell Reports, 2016 STAT5, a member of the family of signal transducers and activators of transcription, senses cytokines and controls the biology of cell lineages, including mammary, liver, and T cells.
Xianke Zeng +4 more
doaj +1 more source
Altered Cytokine-Induced STAT3 and STAT5 Activation of Peripheral T Follicular Helper Cells Contributes to Vaccine-Non-Responsiveness in Aging and HIV. [PDF]
Aging CellChronic immune activation and inflammation associated with aging and HIV skew Tfh signaling toward enhanced IL‐2–STAT5 activation, reinforcing IL‐2R expression through a positive feedback loop and suppressing Tfh helper differentiation programs, thereby contributing to impaired vaccine responsiveness.
Davis S +4 more
europepmc +2 more sources
Neurobiology of Disease, 2007 The signal transducers and activators of transcription (STAT) proteins are a group of transcriptional factors. Among them, STAT5 initiates a pro-survival signaling cascade.
Feng Zhang +4 more
doaj +1 more source
O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies [PDF]
Leukemia, 2017 The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells. Upon cytokine stimulation, STAT5 tyrosine phosphorylation (pYSTAT5) is transient, while in diverse neoplastic cells persistent overexpression and enhanced pYSTAT5 are frequently found.
Freund, P +13 more
openaire +5 more sources
Jak2-Stat5 Interactions Analyzed in Yeast [PDF]
Journal of Biological Chemistry, 1998 Many cytokine receptors employ Janus protein tyrosine kinases (Jaks) and signal transducers and activators of transcription (Stats) for nuclear signaling. Here, we have established yeast strains in which an autoactivated Jak2 kinase induces tyrosine phosphorylation, dimerization, nuclear translocation, and DNA binding of a concomitantly expressed Stat5
F, Barahmand-Pour +3 more
openaire +2 more sources
Stafiba: A STAT5‐Selective Small‐Molecule Inhibitor
ChemBioChem, 2022 AbstractThe transcription factors STAT5a and STAT5b are constitutively active in many human tumors. Combined inhibition of both STAT5 proteins is a valuable approach with promising applications in tumor biology. We recently reported resorcinol bisphosphate as a moderately active inhibitor of the protein‐protein interaction domains, the SH2 domains, of ...
Katrin S. Eckhardt +3 more
openaire +3 more sources
STAT5 isoforms: controversies and clarifications [PDF]
Biochemical Journal, 2007 STAT (signal transducer and activator of transcription) family transcription factors are critical regulators of the development and differentiation of many cell types. STAT isoforms are generated by alternative splicing, but have also been suggested to be generated post-transcriptionally.
Haydeé L. Ramos +2 more
openaire +3 more sources
Chinese Journal of Lung Cancer, 2013 Background and objective It has been proved that cyclooxygenase-2 (COX-2) is a key factor in lung cancer oncogenesis. COX-2 can be induced by a number of cytokines and growth factors and can be regulated by the JAK/STAT signaling pathway.
Jian CUI +7 more
doaj +1 more source
STAT5 regulation of BCL10 parallels constitutive NFκB activation in lymphoid tumor cells
Molecular Cancer, 2009 Background Signal Transducer and Activator of Transcription 5 A and B (STAT5) are key survival factors in cells of the lymphoid lineage. Identification of novel, tissue-specific STAT5 regulated genes would advance the ability to combat diseases due to ...
Mitra Abhisek +5 more
doaj +1 more source