Results 241 to 250 of about 30,689 (278)
Structural basis for DNA recognition by STAT6 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance STAT6 is a transcription factor and plays a predominant role in IL-4/IL-13 and virus-mediated signaling pathways. Extensive studies have linked malfunctions of STAT6 to pathological features of asthma and cancer. Targeting the function of STAT6 has become an attractive therapy.
Mengchen Pu, Qiang Shao, Gonghong Wei
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STAT6 is amplified in a subset of dedifferentiated liposarcoma [PDF]
Modern Pathology, 2014 A recurrent intrachromosomal rearrangement on chromosome 12q in solitary fibrous tumor leads to the formation of a NAB2-STAT6 fusion oncogene. As a result, nuclear expression of the cytoplasmic transcription factor STAT6 is found in solitary fibrous tumor and serves as a useful diagnostic marker.
Adrian Mariño-Enríquez, Leona A Doyle
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Photocontrol of STAT6 dimerization and translocation
Molecular BioSystems, 2010Abstract Phosphorylation of signal transducers and activators of transcription (STAT) proteins is a key step in activation of the JAK–STAT signal transduction cascade. Here we describe an approach to selectively analyze the impact of STAT6 phosphorylation on STATdimerization, DNA binding and nuclear import by accessing six types of ...
Lahiri, S. +3 more
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Brain Tumor Pathology, 2016
This report describes clinicopathological findings, including genetic data of STAT6, in a solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) of the central nervous system in an 83-year-old woman with a bulge in the left forehead. She noticed it about 5 months before, and it had grown rapidly for the past 1 month.
Keisuke, Ishizawa +7 more
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This report describes clinicopathological findings, including genetic data of STAT6, in a solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) of the central nervous system in an 83-year-old woman with a bulge in the left forehead. She noticed it about 5 months before, and it had grown rapidly for the past 1 month.
Keisuke, Ishizawa +7 more
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IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells.
Journal of immunology (Baltimore, Md. : 1950), 1999IFN-alpha consists of a family of highly homologous proteins, which exert pleiotropic effects on a wide variety of cell types. The biologic activities of IFN-alpha are mediated by its binding to a multicomponent receptor complex resulting in the activation of the Janus kinase-STAT signaling pathway.
S, Gupta, M, Jiang, A B, Pernis
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STAT6 is not expressed in Kaposi sarcoma
Annals of Diagnostic Pathology, 2021Georgia, Karpathiou +2 more
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Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery, 2011
To study the distribution and expression of STAT6 and to examine the suggested roles of STAT6 in the pathogenesis of eosinophil infiltration in nasal polyps and to evaluate the role of STAT6 in the pathogenesis of nasal polyps.All selected cases met the enrollment criteria.
Qingsong, Cao +4 more
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To study the distribution and expression of STAT6 and to examine the suggested roles of STAT6 in the pathogenesis of eosinophil infiltration in nasal polyps and to evaluate the role of STAT6 in the pathogenesis of nasal polyps.All selected cases met the enrollment criteria.
Qingsong, Cao +4 more
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STAT6 in PMBL: pathogenic or passenger?
Blood, 2009In this issue of Blood , Ritz and colleagues report that mutations in the transcription factor STAT6 are common events in PMBL. As the treatment of hematologic cancers evolves from nonspecific cytotoxic drugs to targeted rationally designed therapies, the necessity for identifying key ...
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STAT6 joins the gain-of-function club
Journal of Allergy and Clinical Immunology, 2023Karin, Chen +2 more
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