Results 31 to 40 of about 1,054,626 (242)

Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathwayResearch in context

EBioMedicine, 2019
Background: We previously found that loss of lncRNA-AZIN2 splice variant (AZIN2-sv) increases cardiomyocyte (CM) proliferation and attenuates adverse ventricular remodelling post-myocardial infarction (MI).
Xinzhong Li, Yili Sun, Senlin Huang, Yanmei Chen, Xiaoqiang Chen, Mengsha Li, Xiaoyun Si, Xiang He, Hao Zheng, Lintao Zhong, Yang Yang, Wangjun Liao, Yulin Liao, Guojun Chen, Jianping Bin   +14 more
doaj   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source

Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study

Biology of Sex Differences, 2022
Highlights 1. Glucosamine use was associated with lower risk of incident gout in females. 2. The inverse association between glucosamine use and gout was stronger in females with diuretics use. 3. Gout genetic risk scores did not significantly modify the
Mengyi Liu, Ziliang Ye, Yanjun Zhang, Sisi Yang, Qimeng Wu, Chun Zhou, Panpan He, Yuanyuan Zhang, Xiaoqin Gan, Xianhui Qin   +9 more
doaj   +1 more source

Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosisResearch in context

EBioMedicine, 2022
Summary: Background: The role of the IL6 family members in organ fibrosis, including renal interstitial fibrosis (TIF), has been widely explored. However, few studies have ever simultaneously examined them in the same cohort of patients.
Shihui Xu, Xiaobing Yang, Qingzhou Chen, Zhuoliang Liu, Ying Chen, Xiaotian Yao, An Xiao, Jianwei Tian, Liling Xie, Miaomiao Zhou, Zheng Hu, Fengxin Zhu, Xin Xu, Fanfan Hou, Jing Nie   +14 more
doaj   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease

npj Digital Medicine, 2023
Evidence regarding the association between physical activity and Parkinson’s disease (PD) risk is generally limited due to the use of self-report questionnaires.
Mengyi Liu, Xiaoqin Gan, Ziliang Ye, Yuanyuan Zhang, Panpan He, Chun Zhou, Sisi Yang, Yanjun Zhang, Xianhui Qin   +8 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

STATE FAILURE IN WEAK STATES [PDF]

, 1995
This chapter examines the implications of the new institutional economics (NIE) for analysing state failure in developing countries. The NIE approach aims to identify the institutional causes of state failure. In their chapters Bates and Toye have argued that the economic consequences of particular institutions depend on the social and political ...
openaire   +2 more sources

METTL3 Induces AAA Development and Progression by Modulating N6-Methyladenosine-Dependent Primary miR34a Processing

Molecular Therapy: Nucleic Acids, 2020
Identifying effective drugs to delay the progression of aortic aneurysms is a formidable challenge in vascular medicine. Methyltransferase-like 3 (METTL3) plays a key role in catalyzing the formation of N6-methyladenosine (m6A), but despite the ...
Lintao Zhong, Xiang He, Haoyu Song, Yili Sun, Guojun Chen, Xiaoyun Si, Jie Sun, Xiaoqiang Chen, Wangjun Liao, Yulin Liao, Jianping Bin   +10 more
doaj   +1 more source