Results 71 to 80 of about 4,107,771 (287)

scIVNL-seq resolves in vivo single-cell RNA dynamics of immune cells during Salmonella infection

Nature Communications
The immune response against pathogens involves multiple cell state transitions and complex gene expression changes. Here, we establish a single-cell in vivo new RNA labeling sequencing method (scIVNL-seq) and apply it to survey time-resolved RNA dynamics
Zhen Xiong, Runyuan Wu, Yuanxin Wang, Yuwei Xu, Cunzhen Li, Deyuan Kong, Ziqi Xiao, Peikang Zhang, Zhonglong Wang, Peng Zhang, Ying Du, Hui Guo, Pingping Zhu, Shunmin He, Zusen Fan   +14 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Function of ZmBT2a gene in resistance to pathogen infection in maize

Phytopathology Research
The BTB-TAZ protein is a subfamily of the BTB protein family and plays a crucial regulatory role in plant resistance to pathogen infection. However, the function of the maize BTB-TAZ protein ZmBT2a in maize resistance to pathogens has not been reported ...
Fan Zhou, Yonggui Wang, Pengfei Liu, Wenxiao Ma, Ruobing He, Hongzhe Cao, Jihong Xing, Kang Zhang, Jingao Dong   +8 more
doaj   +1 more source

Fiscal regulation and expenditure pattern in Maharashtra state [PDF]

The Fiscal Responsibility and Budgetary Management Act of 2004 has improved state finances of Maharashtra, India. It has also reduced fiscal deficit for state.
Rode, Sanjay
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Analysis and prediction of LUCC change in Huang-Huai-Hai river basin

Open Geosciences, 2020
Land use/cover change plays an important role in human development and environmental health and stability. Markov chain and a future land use simulation model were used to predict future change and simulate the spatial distribution of land use in the ...
Wang Jianwei, Wang Kun, Qin Tianling, Nie Hanjiang, Lv Zhenyu, Liu Fang, Shi Xiaoqing, Hu Yong   +7 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Comprehensive Analysis of Phenotypic Traits in Chinese Cabbage Using 3D Point Cloud Technology

Agronomy
Studies on the phenotypic traits and their associations in Chinese cabbage lack precise and objective digital evaluation metrics. Traditional assessment methods often rely on subjective evaluations and experience, compromising accuracy and reliability ...
Chongchong Yang, Lei Sun, Jun Zhang, Xiaofei Fan, Dongfang Zhang, Tianyi Ren, Minggeng Liu, Zhiming Zhang, Wei Ma   +8 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source