Results 41 to 50 of about 226,308 (303)

European and US Guideline‐Based Statin Eligibility, Genetically Predicted Coronary Artery Disease, and the Risk of Major Coronary Events

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background A study was designed to investigate whether the coronary artery disease polygenic risk score (CAD‐PRS) may guide lipid‐lowering treatment initiation as well as deferral in primary prevention beyond established clinical risk scores. Methods and
Hanjin Park, Daehoon Kim, Seng Chan You, Eunsun Jang, Hee Tae Yu, Tae‐Hoon Kim, Dong‐min Kim, Jung‐Hoon Sung, Hui‐Nam Pak, Moon‐Hyoung Lee, Pil‐Sung Yang, Boyoung Joung   +11 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Statin intensity and postoperative mortality following open repair of intact abdominal aortic aneurysm. [PDF]

, 2018
BackgroundThere is a lack of evidence for the association between intensive statin therapy and outcomes following vascular surgery. The aim of this study was to evaluate the association between perioperative statin intensity and in-hospital mortality ...
Alshaikh, HN, Bohsali, F, Gani, F, Malas, M, Nejim, B   +4 more
core  

Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series. [PDF]

, 2015
Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the literature regarding statin-associated mood/behavioral changes remains limited.
Cham, Stephanie, Golomb, Beatrice A, Koslik, Hayley J   +2 more
core   +1 more source

Biologics May Prevent Cardiovascular Events in Rheumatoid Arthritis by Inhibiting Coronary Plaque Formation and Stabilizing High-Risk Lesions. [PDF]

, 2020
ObjectiveTo evaluate whether biologic disease-modifying antirheumatic drugs (DMARDs) decrease cardiovascular disease (CVD) risk in rheumatoid arthritis (RA) and whether biologic DMARDs might have a beneficial effect on coronary plaque formation or ...
Budoff, Matthew J, Hernandez, Elizabeth, Karpouzas, George A, Ormseth, Sarah R   +3 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Statin non-adherence: clinical consequences and proposed solutions [version 1; referees: 2 approved]

F1000Research, 2016
Large controlled clinical trials have demonstrated reductions with statin therapy in cardiovascular events in patients presenting with acute coronary syndromes and stable coronary heart disease and individuals at high risk of a cardiovascular event.
Robert S. Rosenson
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Statin Use Among Women and Men Following Coronary Artery Bypass Surgery

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Limited data exist on sex differences in guideline‐recommended statin therapy for secondary prevention after coronary artery bypass surgery (CABG).
Sigrid Sandner, Alexandra Kaider, Julia Riebandt, Alissa Florian, Selma Rizvanovic, C. Noel Bairey Merz, Jennifer S. Lawton, Mary Charlson, Monika M. Safford, Thomas Bergmair, Andreas Zuckermann, Mario Gaudino   +11 more
doaj   +1 more source

Identifying Reasons for Statin Nonuse in Patients With Diabetes Using Deep Learning of Electronic Health Records

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Statins are guideline‐recommended medications that reduce cardiovascular events in patients with diabetes. Yet, statin use is concerningly low in this high‐risk population.
Ashish Sarraju, Alban Zammit, Summer Ngo, Celeste Witting, Tina Hernandez‐Boussard, Fatima Rodriguez   +5 more
doaj   +1 more source