Results 41 to 50 of about 141,213 (164)

Efficacy, safety and tolerability of ongoing statin plus ezetimibe versus doubling the ongoing statin dose in hypercholesterolemic Taiwanese patients: an open-label, randomized clinical trial

BMC Research Notes, 2012
Background Reducing low-density lipoprotein cholesterol (LDL-C) is associated with reduced risk for major coronary events. Despite statin efficacy, a considerable proportion of statin-treated hypercholesterolemic patients fail to reach therapeutic LDL-C ...
Yu Chih-Chieh, Lai Wen-Ter, Shih Kuang-Chung, Lin Tsung-Hsien, Lu Chieh-Hua, Lai Hung-Jen, Hanson Mary E, Hwang Juey-Jen   +7 more
doaj   +1 more source

Effect of Statins in Patients With Hemodialysis‐Dependent Chronic Kidney Disease: A Nationwide Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Guidelines for lipid‐lowering therapy in patients with dialysis‐dependent chronic kidney disease remain ambiguous. We aimed to explore cardiovascular outcomes associated with statin use in patients with hemodialysis‐dependent chronic kidney ...
Minyoul Baik, Jimin Jeon, Joonsang Yoo, Jinkwon Kim   +3 more
doaj   +1 more source

Pharmacoepidemiology of statins

Therapies, 2019
The evaluation of the real-life benefits and risks of statins in population is a major pharmacoepidemiological issue, given their widespread use for cardiovascular prevention. The purpose of this review was not to be exhaustive but to show the contributions of pharmacoepidemiology for various aspects of the evaluation of statins such as real-life drug ...
Julien, Bezin, Nicholas, Moore
openaire   +3 more sources

Statins and Risk of Intracerebral Haemorrhage in a Stroke-Free Population: A Nationwide Danish Propensity Score Matched Cohort Study

EClinicalMedicine, 2019
Background: Statins may increase the risk of intracerebral haemorrhage (ICH) in individuals with previous stroke. It remains unclear whether this applies to individuals with no history of stroke.
Anette Riisgaard Ribe, Claus Høstrup Vestergaard, Mogens Vestergaard, Morten Fenger-Grøn, Henrik Schou Pedersen, Lone Winther Lietzen, Peter Krogh Brynningsen   +6 more
doaj   +1 more source

Effects of statins on the development of sepsis and organ dysfunction in hospitalized older patients in China

Brazilian Journal of Infectious Diseases, 2017
This study aimed to evaluate the protective role of statins on the development of sepsis and infection-related organ dysfunction and mortality in a hospitalized older Chinese population with bacterial infections.
Qifeng Gui, Yunmei Yang, Jiajia Zhang
doaj   +1 more source

Statin adherence is lower in primary than secondary prevention: A national follow-up study of new users.

PLoS ONE, 2020
BackgroundMaintaining adherence to statins reduces the risk of an initial cardiovascular disease (CVD) event in high-risk individuals (primary prevention) and additional CVD events following the first event (secondary prevention).
Finn Sigglekow, Simon Horsburgh, Lianne Parkin   +2 more
doaj   +1 more source

Statin therapy is associated with improved survival in patients with ventricular tachyarrhythmias

Lipids in Health and Disease, 2019
Objectives The study sought to assess the impact of statin therapy on survival in patients presenting with ventricular tachyarrhythmias. Background Data regarding the outcome of patients with statin therapy presenting with ventricular tachyarrhythmias is
Jonas Rusnak, Michael Behnes, Tobias Schupp, Siegfried Lang, Linda Reiser, Gabriel Taton, Armin Bollow, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Uzair Ansari, Ibrahim El-Battrawy, Thomas Bertsch, Christoph A. Nienaber, Muharrem Akin, Kambis Mashayekhi, Christel Weiß, Martin Borggrefe, Ibrahim Akin   +18 more
doaj   +1 more source

The pharmacology of statins

Pharmacological Research, 2014
Statins, inhibitors of the hydroxymethylglutaryl-CoA (HMG-CoA) reductase enzyme, are molecules of fungal origin. By inhibiting a key step in the sterol biosynthetic pathway statins are powerful cholesterol lowering medications and have provided outstanding contributions to the prevention of cardiovascular disease. Their detection in mycetes traces back
openaire   +2 more sources

Statins [PDF]

Vascular Medicine, 2017
Elizabeth V, Ratchford, Seth S, Martin
openaire   +2 more sources

Short- and Long-Term Statin Persistence and Determinants in Patients Initiating Statin Therapy

Medeniyet Medical Journal
Objective: Despite the established efficacy of statins in reducing major cardiovascular events and mortality, rates of statin persistence remain low.
Mehmet UZUNLULU, Cundullah TORUN, Erhan EKEN, Gizem AYASGIL ULAS, Lütfullah CASTUR   +4 more
doaj   +1 more source