Results 91 to 100 of about 119,942 (261)
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, EarlyView.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Effect of Statin Lipophilicity on the Proliferation of Hepatocellular Carcinoma Cells
BiologyThe HMG-CoA reductase inhibitors, statins, are drugs used globally for lowering the level of cholesterol in the blood. Different clinical studies of statins in cancer patients have indicated a decrease in cancer mortality, particularly in patients using ...
Goda Glebavičiūtė +2 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract This study investigated the attitudes and beliefs of older adults towards deprescribing statins in Australia, the United Kingdom and the United States, using an online, vignette‐based study. Presented with a hypothetical scenario in which a general practitioner advised stopping simvastatin, participants rated their level of agreement and ...
Sarah E. Vordenberg +5 more
wiley +1 more source
Clinical repercussions of statin use during pregnancy: a review of the literature
Revista Brasileira de Ginecologia e ObstetríciaStatins are the most widely used pharmacological class for treating hyperlipidemia, although they are contraindicated during pregnancy. This study aims to demonstrate the clinical effects of statins in pregnant women through an interactive review ...
Joan Lins Serafim +7 more
doaj +1 more source
GLP‐1 agonists and the gut microbiome: A bidirectional relationship
British Journal of Clinical Pharmacology, EarlyView.Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath +2 more
wiley +1 more source
APOE genotype and the effect of statins on lipid outcomes: A meta‐analysis
British Journal of Clinical Pharmacology, EarlyView.Aim APOE genotype may affect statin therapy response. We conducted a meta‐analysis to update and quantify this association across various outcomes. Methods We searched seven databases (MEDLINE, Scopus, Web of Science, the Cochrane Library, APA PsycINFO, CINAHL Plus and ClinicalTrials.gov) on 9 May 2024.
Innocent G. Asiimwe +4 more
wiley +1 more source
Crestal approach for repair of oroantral bone defects and subsequent implant placement
Clinical Advances in Periodontics, EarlyView.Abstract Background Oroantral communication (OAC) can occur after a dental extraction. Occasionally, bony defects may persist despite successful soft tissue closure of the OAC. The absence of bone in these areas poses challenges for dental implant placement.
Min Yang +3 more
wiley +1 more source
The molecular basis of the anticancer effect of statins
Scientific ReportsStatins, widely used cardiovascular drugs that lower cholesterol by inhibiting HMG-CoA reductase, have been increasingly recognized for their potential anticancer properties.
Giovanni Buccioli +6 more
doaj +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background Trans‐catheter aortic valve replacement (TAVR) in patients with large annuli poses procedural difficulties and possible complications. Aims We sought to compare the peri‐procedural and long‐term outcomes of patients with large annuli undergoing TAVR with self‐expanding (SEV) versus balloon‐expandable (BEV) valves.
Lior Zornitzki +12 more
wiley +1 more source