Results 231 to 240 of about 154,404 (310)

Low testosterone levels in men at age 31 associates with future risk of prediabetes and type 2 diabetes: A birth cohort study

Andrology, EarlyView.
Abstract Objective We aimed to investigate the association of a low serum testosterone concentration with the risk of abnormal glucose metabolism (i.e., prediabetes and type 2 diabetes) in men at a 15‐year follow‐up. Study population and methods In a population birth cohort, men with low testosterone (testosterone < 12.1 nmol/L, n = 136) and normal ...
Tuomisto A, Pinola P, Pesonen P, Franks S, Martikainen H, Tapanainen JS, Niinimäki M, Morin‐Papunen L   +7 more
wiley   +1 more source

Are statins a promising therapeutic strategy for macular edema? Insights from a systematic review and meta-analysis. [PDF]

Int J Retina Vitreous
Chen KY, Chan HC, Chan CM.
europepmc   +1 more source

Healthy Aging Men Do Not Suffer From Relevant Limitations of Their Reproductive Functions

Andrology, EarlyView.
Abstract Background While metabolic disorders are well‐established contributors to testosterone decline and erectile dysfunction (ED), little is known about the natural progression of reproductive parameters in healthy aging men. Objectives This study aimed to evaluate longitudinal changes in reproductive parameters and sought to determine the ...
Simone Bier, Jann‐Frederik Cremers, Phillip Schrage, Amelie Körtje, Claudia Krallmann, Sabine Kliesch, Jörg Gromoll, Sandra Laurentino, Michael Zitzmann   +8 more
wiley   +1 more source

Association Between Statins Use and Major Bleeding in Patients Using Direct Oral Anticoagulants for Atrial Fibrillation. [PDF]

Pharmacoepidemiol Drug Saf
de Burgos-González A, Cea-Soriano L, Huerta-Álvarez C.   +2 more
europepmc   +1 more source

Spontaneous Bacterial Peritonitis Is Associated With High Mortality, Which Interacts With Antibiotic Prophylaxis in a National Cirrhosis Cohort

Alimentary Pharmacology &Therapeutics, EarlyView.
In a national cohort of newly decompensated Veterans with cirrhosis, SBP and recurrences are linked with higher death and need for liver transplant. SBP prophylaxis, whether primary or secondary, worsens resistance and interacts with mortality but not liver transplant.
Scott Silvey, Nilang Patel, Jacqueline G. O'Leary, Timothy Morgan, John D. Markley, Sofia S. Jakab, Heather Patton, Shari Rogal, Jasmohan S. Bajaj   +8 more
wiley   +1 more source

Statin Therapy Independently Reduces Mortality and Liver Complications in Patients With Cirrhosis: An Updated Systematic Review and Meta‐Analysis

Alimentary Pharmacology &Therapeutics, EarlyView.
Statin therapy in cirrhosis may confer a survival benefit while reducing the risk of hepatic decompensation and hepatocellular carcinoma. ABSTRACT Background The role of statins in cirrhosis remains controversial. Historically restricted due to safety concerns, emerging evidence highlights potential pleiotropic benefits, though effects on mortality and
Bernardo de Faria Moraes, Gustavo André Pedral Diniz Leite, Igor Boechat Silveira, Gabriel André Pedral Diniz Leite, Maria Luisa Motta Fonseca, Leonardo Corrêa Suffert, Luisa Medeiros Visentini, Luis Pedro Possapp Beis, Guilherme Grossi Lopes Cançado   +8 more
wiley   +1 more source

Impact of statin therapy on postoperative outcomes following colorectal cancer surgery: A systematic review. [PDF]

World J Gastrointest Surg
Mohsin S, Hasan M, Mustafa F, Kumar J, Aleissa M, Bhullar JS, Kumar S.   +6 more
europepmc   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Low-dose Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB. [PDF]

Cell Oncol (Dordr)
Wang Z, Wu D, Zhang Y, Chen W, Fan S, Yang Y, Yang Y, Zu G, An Y, Jin Y, Kang A, Zou Y, Liu Y, Yu X, Qin Y, Xu X, Chen X.   +16 more
europepmc   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source