Results 271 to 280 of about 216,413 (307)
Some of the next articles are maybe not open access.
Intensive and Critical Care Nursing, 2004
High plasma cholesterol levels lead to the formation of atheromatous plaques in blood vessels, and this can ultimately lead to obstruction or occlusion of the vessel. Cholesterol is transported in the blood as lipoproteins, which can be either low density or high density.
openaire +3 more sources
High plasma cholesterol levels lead to the formation of atheromatous plaques in blood vessels, and this can ultimately lead to obstruction or occlusion of the vessel. Cholesterol is transported in the blood as lipoproteins, which can be either low density or high density.
openaire +3 more sources
Immunologic Research, 2013
Statins have immunomodulatory effects. Hence, they could be advantageous for different reasons. First, statins can serve as adjunct therapy in autoimmune diseases. Second, they may play a role in the prevention of accelerated atherosclerosis in the same population. In this review, we discuss the mechanisms of immune regulation by statins and review the
Saakshi, Khattri +1 more
openaire +2 more sources
Statins have immunomodulatory effects. Hence, they could be advantageous for different reasons. First, statins can serve as adjunct therapy in autoimmune diseases. Second, they may play a role in the prevention of accelerated atherosclerosis in the same population. In this review, we discuss the mechanisms of immune regulation by statins and review the
Saakshi, Khattri +1 more
openaire +2 more sources
The Lancet, 1999
Sir—Robert Rosenson and colleagues (March 20, p 983) investigate whether pravastatin modifies the production o f proinflammatory cytokines that regulate vascular tone, plaque stability, and thrombogenesis. They measured concentrations of peripheral blood samples after 6 h of incubation with lipopolysaccharide (LPS) and showed that LPS-stimulated ...
U, Ikeda, K, Shimada
openaire +2 more sources
Sir—Robert Rosenson and colleagues (March 20, p 983) investigate whether pravastatin modifies the production o f proinflammatory cytokines that regulate vascular tone, plaque stability, and thrombogenesis. They measured concentrations of peripheral blood samples after 6 h of incubation with lipopolysaccharide (LPS) and showed that LPS-stimulated ...
U, Ikeda, K, Shimada
openaire +2 more sources
BMJ, 2014
The UK National Institute for Health and Care Excellence has issued new guidelines on lipid lowering. The headlines are: lower the treatment threshold for primary prevention to people with a 10 year risk of 10%, use atorvastatin preferentially, and use the Qrisk assessment tool.1 This guidance, authored by a small group of important cholesterol ...
openaire +2 more sources
The UK National Institute for Health and Care Excellence has issued new guidelines on lipid lowering. The headlines are: lower the treatment threshold for primary prevention to people with a 10 year risk of 10%, use atorvastatin preferentially, and use the Qrisk assessment tool.1 This guidance, authored by a small group of important cholesterol ...
openaire +2 more sources
Expert Opinion on Investigational Drugs, 2001
The beneficial effect of beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) in primary prevention of coronary artery disease in those with hypercholesterolaemia and in secondary prevention in those with established coronary vascular disease are now well known.
N, Delanty, C J, Vaughan, N, Sheehy
openaire +2 more sources
The beneficial effect of beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) in primary prevention of coronary artery disease in those with hypercholesterolaemia and in secondary prevention in those with established coronary vascular disease are now well known.
N, Delanty, C J, Vaughan, N, Sheehy
openaire +2 more sources
Seminars in Vascular Medicine, 2004
Lipid abnormalities play an important part in raising the cardiovascular risk in diabetic subjects. The main components of diabetic dyslipidemia are increased plasma triglycerides, low concentration of high-density lipoprotein cholesterol, preponderance of small, dense low-density lipoprotein, and excessive postprandial lipemia.
Rafael, Carmena, D John, Betteridge
openaire +2 more sources
Lipid abnormalities play an important part in raising the cardiovascular risk in diabetic subjects. The main components of diabetic dyslipidemia are increased plasma triglycerides, low concentration of high-density lipoprotein cholesterol, preponderance of small, dense low-density lipoprotein, and excessive postprandial lipemia.
Rafael, Carmena, D John, Betteridge
openaire +2 more sources
Medicina Clínica (English Edition), 2015
Statins are the most widely used drugs for both primary and secondary prevention of cardiovascular diseases and those associated with atherosclerosis. About 25 million people are on statin therapy in the world. Although they are well tolerated by most patients and have a safety profile, some patients have muscle level alterations.
Marcelo, Alvarado Cárdenas +2 more
openaire +2 more sources
Statins are the most widely used drugs for both primary and secondary prevention of cardiovascular diseases and those associated with atherosclerosis. About 25 million people are on statin therapy in the world. Although they are well tolerated by most patients and have a safety profile, some patients have muscle level alterations.
Marcelo, Alvarado Cárdenas +2 more
openaire +2 more sources
Current Atherosclerosis Reports, 2007
The incidence and prevalence of dementia are increasing. Dementia is a major cause of disability. Alzheimer's disease (AD) is the most common type of dementia. There are no good prevention or treatment options. Experimental animal and laboratory studies have suggested that cholesterol metabolism in the brain is important in the causal pathway for ...
openaire +2 more sources
The incidence and prevalence of dementia are increasing. Dementia is a major cause of disability. Alzheimer's disease (AD) is the most common type of dementia. There are no good prevention or treatment options. Experimental animal and laboratory studies have suggested that cholesterol metabolism in the brain is important in the causal pathway for ...
openaire +2 more sources
Vascular Pharmacology, 2007
Statins have been shown to have pleiotropic effects apart from serum lipid-lowering effect in human. One of the major target organs for the effects of statins is the vascular endothelium, which plays an important role in the development of atherosclerosis and angiogenesis.
Masaaki, Ii, Douglas W, Losordo
openaire +2 more sources
Statins have been shown to have pleiotropic effects apart from serum lipid-lowering effect in human. One of the major target organs for the effects of statins is the vascular endothelium, which plays an important role in the development of atherosclerosis and angiogenesis.
Masaaki, Ii, Douglas W, Losordo
openaire +2 more sources
BMJ, 2014
Lots of lessons, but we still need the data An expert panel convened by The BMJ has concluded that two articles published last year1 2 and corrected in May should not be retracted.3 The panel’s report comes after a lengthy and public row over proposals to extend the use of statins to healthy people at low risk of heart disease.4 What are the lessons ...
openaire +2 more sources
Lots of lessons, but we still need the data An expert panel convened by The BMJ has concluded that two articles published last year1 2 and corrected in May should not be retracted.3 The panel’s report comes after a lengthy and public row over proposals to extend the use of statins to healthy people at low risk of heart disease.4 What are the lessons ...
openaire +2 more sources