Results 71 to 80 of about 154,404 (310)
Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome
Advanced Science, EarlyView.Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger +11 morewiley +1 more sourceCirculating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness
Hepatology, EarlyView., 2022 Abstract Background and Aims
Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen +17 morewiley +1 more sourceStudy protocol and baseline characteristics of Randomized trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy–Statin and Eicosapentaenoic Acid: RESPECT-EPA, the combination of a randomized control trial and an observational biomarker study
, 2022 Yuji Nishizaki, Katsumi Miyauchi, Hiroshi Iwata, Teruo Inoue, Atsushi Hirayama, Kazuo Kimura, Yukio Ozaki, Toyoaki Murohara, Kenji Ueshima, Yoshihiro Kuwabara, Sachiko Tanaka-Mizuno, Naotake Yanagisawa, Tosiya Sato, Hiroyuki Daida +13 moreopenalex +1 more sourceCholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation
Advanced Science, EarlyView.Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu +14 morewiley +1 more sourceApolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism
Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background
NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD, Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas +30 morewiley +1 more sourceModerate-Intensity Statin With Ezetimibe Combination Therapy vs High-Intensity Statin Monotherapy in Patients at Very High Risk of Atherosclerotic Cardiovascular Disease
, 2023 Seung‐Jun Lee, Jung‐Joon Cha, Woong Choi, Wang Soo Lee, Jin‐Ok Jeong, Seonghoon Choi, Yoon-Haeng Cho, Woo Jung Park, Jung‐Kyu Han, Yong‐Joon Lee, Sung‐Jin Hong, Chul‐Min Ahn, Byeong‐Keuk Kim, Young‐Guk Ko, Donghoon Choi, Myeong‐Ki Hong, Yangsoo Jang, Soon Jun Hong, Jung‐Sun Kim, Kyeong Ho Yun, Bum‐Kee Hong, Jung Ho Heo, Won Young Jang, Won‐Yong Shin, Sang Wook Im, Woong Chol Kang, Young Hoon Jung, Yongwhi Park, Sung Yoon Lee, Seung‐Ho Hur, Hyun Hee Choi, Kyoung Jin Kim, Ju Han Kim, Hyun Kuk Kim, Jung Hee Lee, Ung Kim, Yujung Choi, Seung‐Woon Rha, Yun‐Hyeong Cho, Yun-Hyeong Cho +39 moreopenalex +2 more sourcesAmyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles
Annals of Neurology, EarlyView.Objective
Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.Christos V. Chalitsios, Jiali Gao, Carol A.C. Coupland, Julia Hippisley Cox, Martin R. Turner, Alexander G. Thompson +5 morewiley +1 more source
