Results 71 to 80 of about 2,851,799 (287)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Cohomology of D-complex manifolds [PDF]
, 2012 In order to look for a well-behaved counterpart to Dolbeault cohomology in D-complex geometry, we study the de Rham cohomology of an almost D-complex manifold and its subgroups made up of the classes admitting invariant, respectively anti-invariant ...
Daniele Angella +4 more
core +1 more source
The minimal entropy problem for 3-manifolds with zero simplicial volume [PDF]
, 2003 In this note, we consider the minimal entropy problem, namely the question of whether there exists a smooth metric of minimal (topological) entropy, for certain classes of closed 3 ...
Anderson, J.W., Paternain, G.P.
core +1 more source
Robustness of statistical manifolds
Topology and its Applications, 2023 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Loi, A., Matta, S.
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Dehn surgeries and negative-definite four-manifolds [PDF]
, 2012 Given a knot <i>K</i> in the three-sphere, we address the question: Which Dehn surgeries on <i>K</i> bound negative-definite four-manifolds?
Strle, Sašo, Owens, Brendan
core +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Conformal-Projective Geometry of Statistical Manifolds [PDF]
, 2010 application/pdfConformal-projective geometry of statistical manifolds, a natural generalization of conformal geometry of Riemannian manifolds, is studied in this paper.
Kurose, Takashi
core
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source