Results 71 to 80 of about 2,732,414 (284)
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Black-Box Optimization Using Geodesics in Statistical Manifolds
Entropy, 2015 Information geometric optimization (IGO) is a general framework for stochastic optimization problems aiming at limiting the influence of arbitrary parametrization choices: the initial problem is transformed into the optimization of a smooth function on a
Jérémy Bensadon
doaj +1 more source
Robustness of statistical manifolds
Topology and its Applications, 2023 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Loi, A., Matta, S.
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Separating manifolds in slow-fast systems [PDF]
, 2005 There are many applications that lead to models involving different timescales. For example, this is particularly the case for models of neurons, which involve dynamics of ionic channels across the cell membrane.
England, James, Osinga, HM
core
Sasakian Statistical Manifolds with Semi-Symmetric Metric Connection
Universal Journal of Mathematics and Applications, 2018 In the present paper, firstly we express the relation between the semi-symmetric metric connection $\tilde{\nabla}$ and the torsion-free connection $\nabla$ and obtain the relation between the curvature tensors $\tilde{R}$ of $\tilde{\nabla}$ and $R$ of $
Ahmet Kazan, Sema Kazan
doaj +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Kahler manifolds and their relatives [PDF]
, 2010 Let M1 and M2 be two K¨ahler manifolds. We call M1 and M2 relatives if they share a non-trivial K¨ahler submanifold S, namely, if there exist two holomorphic and isometric immersions (K¨ahler immersions) h1 : S → M1 and h2 : S → M2. Moreover, two K¨ahler
Loi, A., Di Scala, Antonio Jose'
core
Entropy, 2022 Possible implications and consequences of using SL(2R) as invariance groups in the description at any scale resolution of the dynamics of any complex system are analyzed.
Lucian Dobreci +8 more
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source