Results 161 to 170 of about 5,852,793 (269)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Evaluating statistical significance in a meta-analysis by using numerical integration. [PDF]

Comput Struct Biotechnol J, 2022
Lin YC, Liang YJ, Yang HC.
europepmc   +1 more source

Common misinterpretations of statistical significance and <i>P</i>-values in dairy research. [PDF]

JDS Commun
Laven R, Yang DA.
europepmc   +1 more source

Variation across analysts in statistical significance, yet consistently small effect sizes. [PDF]

Proc Natl Acad Sci U S A, 2023
Mathur MB, Covington C, VanderWeele TJ.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Survival-inferred fragility of statistical significance in phase III oncology trials. [PDF]

NPJ Precis Oncol
Sherry AD, Liu Y, Msaouel P, Lin TA, Koong A, Lin C, Abi Jaoude J, Patel RR, Kouzy R, El-Alam MB, Miller AM, Owiwi M, Ofer J, Bomze D, McCaw ZR, Meirson T, Ludmir EB.   +16 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

About Research: Clinical Versus Statistical Significance. [PDF]

J Hum Lact
Wouk K, Kenny K, Chetwynd E.
europepmc   +1 more source

Replacing statistical significance and non-significance with better approaches to sampling uncertainty. [PDF]

Front Physiol, 2022
Hopkins WG.
europepmc   +1 more source