Results 91 to 100 of about 48,477 (300)

Steady state mode-locking of a 1.34 μm Nd:YVO4 laser using a single-walled carbon nanotube saturable absorber

, 2011
Steady state mode-locked operation of a neodymium laser operating on the F-4(3/2) -> I-4(13/2) transition around 1.3 mu m is achieved for the first time using transmitting single-walled carbon nanotube (SWCNT) saturable absorber.
K. Kim, V. Petrov, F. Rotermund, S. Y. Choi, Choi, S. Y., Iliev, H., Buchvarov, I., I. Buchvarov, Kim, K., U. Griebner, H. Iliev, Petrov, V., Rotermund, Fabian Marcel, Griebner, U.   +13 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Steady-state modeling of a phase-shift PWM parallel resonant converter [PDF]

, 2006
Purpose - To derive an analytical model for a dc-ac-dc parallel resonant converter operating in lagging power factor mode based on the steady-state operation conditions and considering the effects of a high-frequency ...
Uctug, Yildurum, Iskender, Ires, Ertan, H. Bulent, Ertan, Hulusi Bülent   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Typical Power Grid Operation Mode Generation Based on Reinforcement Learning and Deep Belief Network

, 2023
With the continuous expansion of power grids and the gradual increase in operational uncertainty, it is progressively challenging to meet the capacity requirements for power grid development based on manual experience.
Hongming Yang, Zirui Wang, Chen Lv, Zhao Yang, Quan Ma, Yong Cui, Bowen Zhou   +6 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Modeling and Control of the Distributed Power Converters in a Standalone DC Microgrid

Energies, 2016
A standalone DC microgrid integrated with distributed renewable energy sources, energy storage devices and loads is analyzed. To mitigate the interaction among distributed power modules, this paper describes a modeling and control design procedure for ...
Xiaodong Lu, Jiangwen Wan
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Realization of minute-long steady-state H-mode discharges on EAST

, 2017
In the 2016 EAST experimental campaign, a steady-state long-pulse H-mode discharge with an ITER-like tungsten divertor lasting longer than one minute has been obtained using only RF heating and current drive, through an integrated control of the wall ...
GONG, Xianzu, LIN, Shiyao, ZENG, Long, Mao WANG, Xianzu GONG, WAN, Baonian, GAROFALO, A. M., DING, Siye, HU, Jiansheng, Jiangang LI, ZHAO, Yanping, Youwen SUN, WANG, Mao, HUANG, Juan, ZHANG, Bin, ZANG, Qing, Yanping ZHAO, SUN, Youwen, Ling ZHANG, SHAO, Linming, XIAO, Bingjia, null null, ZHANG, Ling, Long ZENG, Biao SHEN, QIAN, Jinping, Liqun HU, Jinping QIAN, Juan HUANG, LI, Erzhong, XU, Handong, Chundong HU, Siye DING, Guosheng XU, HU, Chundong, LIANG, Yunfeng, Bin ZHANG, XU, Guosheng, Fukun LIU, Bingjia XIAO, XIANG, Nong, LIU, Haiqing, Shiyao LIN, Jiansheng HU, SHEN, Biao, LIU, Fukun, Annika EKEDAH, A M GAROFALO, Haiqing LIU, EKEDAH, Annika, Nong XIANG, Handong XU, Liang WANG, Linming SHAO, Qing ZANG, Erzhong LI, Yunfeng LIANG, Baonian WAN, LI, Jiangang, HU, Liqun, WANG, Liang   +60 more
core   +1 more source