Results 81 to 90 of about 438,567 (296)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
International Transactions on Electrical Energy Systems, 2023 This study deals with an asymmetrical six-phase open-ended winding induction machine in closed loop operation using indirect field-oriented control scheme.
Arif Iqbal +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Task 4 completion report for 40 Kilowatt grid connected modification contract [PDF]
Startup, operation in grid connect mode, shutdown from grid connects, operation in isolated mode, shutdown from isolated mode, steady state operation, mode transfers, and voltage disconnects are ...
Vogt, J. H.
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
, 2020 We explore the consequences of periodically modulating a quantum two-level system (TLS) with an asymmetric pulse when the system is in contact with thermal baths.
A. Rivas +7 more
core +1 more source
Design of high gradient, high repetition rate damped C-band rf structures [PDF]
, 2017 The gamma beam system of the European Extreme Light Infrastructure–Nuclear Physics project foresees the use of a multibunch train colliding with a high intensity recirculated laser pulse. The linac energy booster is composed of 12 traveling wave C-band
Alesini, David +13 more
core +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source