Results 11 to 20 of about 170,525 (342)

Immune cell-mediated features of non-alcoholic steatohepatitis

Nature reviews. Immunology, 2021
Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis (NASH), cirrhosis or even hepatocellular carcinoma. NAFLD is a major health
T. Huby, E. Gautier
semanticscholar   +1 more source

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis [PDF]

, 2020
Background A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1).
Banerjee, R, Banerjee, R, Bell, J.D., Bell, J.D., Hemingway, H., Hemingway, H., Hingorani, A.D., Hingorani, A.D., Kelly, M., Kelly, M., McGonigle, J., McGonigle, J., Neubauer, S., Neubauer, S., Nicholls, R.C., Nicholls, R.C., Parisinos, C.A., Parisinos, C.A., Patel, R.S., Patel, R.S., Thomas, E.L., Thomas, E.L., Wilman, H., Wilman, H., Yaghootkar, H., Yaghootkar, H.   +25 more
core   +3 more sources

Efficacy and Safety of Biphenyl Dimethyl Dicarboxylate and Ursodeoxycholic Acid Combination in Chronic Hepatitis Related to Metabolic Syndrome Components

The Korean Journal of Gastroenterology, 2021
Backgrounds/Aims: Steatohepatitis related to metabolic syndrome is a chronic liver disease prevalent in patients not only with non-alcoholic steatohepatitis but also with alcoholic liver disease and chronic viral hepatitis.
Nae-Yun Heo, Seung Ha Park, Joon Hyuk Choi, Eunju Kim, Tae Oh Kim, Jongha Park, Jin Lee, Yong Eun Park, Eun Hye Oh, Jun Seong Hwang, Su Jin Jeon   +10 more
doaj   +1 more source

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis.

New England Journal of Medicine, 2020
BACKGROUND Nonalcoholic steatohepatitis (NASH) is a common disease that is associated with increased morbidity and mortality, but treatment options are limited.
P. Newsome, Kristine Buchholtz, K. Cusi, Martin Linder, T. Okanoue, V. Ratziu, A. Sanyal, A. Sejling, S. Harrison   +8 more
semanticscholar   +1 more source

The effect of 12 weeks regular physical activity and vitamin E in the treatment of non-alcoholic steatohepatitis: A pilot study [PDF]

, 2015
Background: Despite the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH), there was no treatment has been proven to be effective in these common diseases.
Eslami, L., Isazadehfar, K., Karami, M., Eslami, L., Rahmani-nia, F., Nakhostinroohi, B.   +5 more
core   +7 more sources

Role of Leptin in Non-Alcoholic Fatty Liver Disease

Biomedicines, 2021
Non-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global population, poses a substantial health and economic burden in all countries, yet there is no approved pharmacotherapy to treat this entity, nor well-established ...
Carlos Jiménez-Cortegana, Alba García-Galey, Malika Tami, Pilar del Pino, Isabel Carmona, Soledad López, Gonzalo Alba, Víctor Sánchez-Margalet   +7 more
doaj   +1 more source

Distinct Influence of Hypercaloric Diets Predominant with Fat or Fat and Sucrose on Adipose Tissue and Liver Inflammation in Mice

Molecules, 2020
Overfeeding of a hypercaloric diet leads to obesity, diabetes, chronic inflammation, and fatty liver disease. Although limiting fat or carbohydrate intake is the cornerstone for obesity management, whether lowering fat or reducing carbohydrate intake is ...
Caíque S. M. Fonseca, Joshua E. Basford, David G. Kuhel, Eddy S. Konaniah, James G. Cash, Vera L. M. Lima, David Y. Hui   +6 more
doaj   +1 more source

Beneficial Effects of Opuntia spp. on Liver Health

Antioxidants, 2023
The genus Opuntia spp. includes plants capable of growing in arid, temperate and tropical climates. The vast majority of wild species grow in Mexico, but O.
Irene Besné-Eseverri, Jenifer Trepiana, Saioa Gómez-Zorita, Marilena Antunes-Ricardo, M. Pilar Cano, María P. Portillo   +5 more
doaj   +1 more source

Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis

Clinical and Molecular Hepatology, 2022
The initial presentation of non-alcoholic steatohepatitis (NASH) is hepatic steatosis. The dysfunction of lipid metabolism within hepatocytes caused by genetic factors, diet, and insulin resistance causes lipid accumulation.
Kuei-Chuan Lee, Pei-Shan Wu, Han‐Chieh Lin   +2 more
semanticscholar   +1 more source

Animal models of NASH: getting both pathology and metabolic context right [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease.
Larter, Claire Z., Yeh, Matthew M.
core   +1 more source