Results 211 to 220 of about 89,996 (262)
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Annals of Internal Medicine, 1997
To determine the clinical relevance of nonalcoholic steatohepatitis (NASH) and to review the available literature on the epidemiology, clinical features, histology, pathogenesis, clinical course, and management of this condition.Pertinent articles in English identified through a MEDLINE search (1966 to the present) and the bibliographies of relevant ...
S G, Sheth, F D, Gordon, S, Chopra
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To determine the clinical relevance of nonalcoholic steatohepatitis (NASH) and to review the available literature on the epidemiology, clinical features, histology, pathogenesis, clinical course, and management of this condition.Pertinent articles in English identified through a MEDLINE search (1966 to the present) and the bibliographies of relevant ...
S G, Sheth, F D, Gordon, S, Chopra
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JAMA, 2020
Nonalcoholic steatohepatitis (NASH) is the inflammatory subtype of nonalcoholic fatty liver disease (NAFLD) and is associated with disease progression, development of cirrhosis, and need for liver transplant. Despite its importance, NASH is underrecognized in clinical practice.NASH affects an estimated 3% to 6% of the US population and the prevalence ...
Adam C, Sheka +5 more
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Nonalcoholic steatohepatitis (NASH) is the inflammatory subtype of nonalcoholic fatty liver disease (NAFLD) and is associated with disease progression, development of cirrhosis, and need for liver transplant. Despite its importance, NASH is underrecognized in clinical practice.NASH affects an estimated 3% to 6% of the US population and the prevalence ...
Adam C, Sheka +5 more
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Annual Review of Medicine, 2017
Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide. NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). It is not well understood why some, but not other, individuals with hepatic steatosis develop NASH.
Ayako, Suzuki, Anna Mae, Diehl
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Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide. NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). It is not well understood why some, but not other, individuals with hepatic steatosis develop NASH.
Ayako, Suzuki, Anna Mae, Diehl
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Mitochondria in Steatohepatitis
Seminars in Liver Disease, 2001For the first time in history, populations in affluent countries may concomitantly indulge in rich food and physical idleness. Various combinations of obesity, diabetes, and hypertriglyceridemia, with insulin resistance as the common feature, cause hepatic steatosis, which can trigger necroinflammation and fibrosis.
D, Pessayre +3 more
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Medical Clinics of North America, 1996
NASH is a form of chronic liver disease that is defined by biopsy findings and has the appearance of alcoholic hepatitis. Although this disease was once thought to be a problem of women, diabetics, and the obese, more recent studies have identified a significant proportion of patients who do not fit these risk factors.
B A, Neuschwander-Tetri, B R, Bacon
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NASH is a form of chronic liver disease that is defined by biopsy findings and has the appearance of alcoholic hepatitis. Although this disease was once thought to be a problem of women, diabetics, and the obese, more recent studies have identified a significant proportion of patients who do not fit these risk factors.
B A, Neuschwander-Tetri, B R, Bacon
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Liver Cirrhosis with Steatohepatitis: Nonalcoholic Steatohepatitis and Alcoholic Steatohepatitis
2019Nonalcoholic steatohepatitis is a phenotype of metabolic diseases in the liver, associated with eating disorders and lack of exercise. In contrast, alcoholic steatohepatitis develops due to alcohol abuse. Although the causes are different, each type of steatohepatitis exhibits the same histological features, such as steatosis, lobular and portal ...
Teruki Miyake, Yoichi Hiasa
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Current Opinion in Endocrinology & Diabetes, 1998
NASH is an important form of chronic liver disease that is increasingly recognized. The diagnosis is secured by biopsy findings with similarities to alcoholic hepatitis in a patient with a confirmed history of abstinence. Obesity is a major risk factor, but the disease also occurs in the nonobese.
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NASH is an important form of chronic liver disease that is increasingly recognized. The diagnosis is secured by biopsy findings with similarities to alcoholic hepatitis in a patient with a confirmed history of abstinence. Obesity is a major risk factor, but the disease also occurs in the nonobese.
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Pathogenesis of steatohepatitis
Best Practice & Research Clinical Gastroenterology, 2002Understanding the pathogenesis of non-alcoholic steatohepatitis has recently assumed great importance with the recognition that it has the potential to progress to fibrosis and cirrhosis. The 'two-hit' model of pathogenesis was proposed in 1998, with the first 'hit' - steatosis - increasing the sensitivity of the liver to the second 'hits' mediating ...
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Best Practice & Research Clinical Gastroenterology, 2010
Severe alcoholic steatohepatitis has a poor prognosis and is characterized by jaundice and signs of liver failure. Its incidence is unknown, but prevalence is around 20% in cohorts of alcoholics undergoing liver biopsy. Diagnosis is established with elevated liver transaminases, neutrophil counts, serum bilirubin, and impaired coagulation and a history
Stickel, Felix, Seitz, Helmut K
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Severe alcoholic steatohepatitis has a poor prognosis and is characterized by jaundice and signs of liver failure. Its incidence is unknown, but prevalence is around 20% in cohorts of alcoholics undergoing liver biopsy. Diagnosis is established with elevated liver transaminases, neutrophil counts, serum bilirubin, and impaired coagulation and a history
Stickel, Felix, Seitz, Helmut K
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Seminars in Liver Disease, 2002
In addition to the usual associations with insulin resistance, type 2 diabetes, central obesity, and hypertriglyceridemia, nonalcoholic steatohepatitis (NASH) has been associated with several drugs and toxins. However, drug-induced liver disease is a relatively uncommon cause of steatohepatitis.
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In addition to the usual associations with insulin resistance, type 2 diabetes, central obesity, and hypertriglyceridemia, nonalcoholic steatohepatitis (NASH) has been associated with several drugs and toxins. However, drug-induced liver disease is a relatively uncommon cause of steatohepatitis.
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