Results 31 to 40 of about 170,525 (342)

Pathogenesis of Nonalcoholic Steatohepatitis: An Overview

Hepatology Communications, 2020
Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous group of liver diseases characterized by the accumulation of fat in the liver. The heterogeneity of NAFLD is reflected in a clinical and histologic spectrum where some patients develop isolated ...
G. Parthasarathy, X. Revelo, H. Malhi
semanticscholar   +1 more source

Obeticholic acid and ferrostatin-1 differentially ameliorate non-alcoholic steatohepatitis in AMLN diet-fed ob/ob mice

Frontiers in Pharmacology, 2022
Introduction: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are common chronic liver diseases with limited treatment options.Methods: Ob/ob mice (6 weeks old) were fed with the Control diet or amylin liver NASH (AMLN)
Shengjie Li, Aoxiang Zhuge, Kaicen Wang, Jiafeng Xia, Qiangqiang Wang, Shengyi Han, Jian Shen, Lanjuan Li, Lanjuan Li   +8 more
doaj   +1 more source

A Prospective Study of Long-term Outcomes in Female Patients with Nonalcoholic Steatohepatitis Using Age- and Body Mass Index-matched Cohorts [PDF]

, 2013
In patients with nonalcoholic steatohepatitis (NASH), the prevalence of cirrhosis is higher among women than men, and hepatocellular carcinoma (HCC) develops mainly in the cirrhotic stage among women.
Hashizume, Hiroaki, Horiguchi, Norio, Kakizaki, Satoru, Mori, Masatomo, Sato, Ken, Yamazaki, Yuichi   +5 more
core   +1 more source

Genetic predictors and pathophysiological features of non-alcoholic fat liver disease

Медицинский совет, 2021
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in highly developed countries. The risk of developing NAFLD and associated complications varies greatly among people of different nationalities and is determined by ...
O. V. Smirnova, O. L. Moskalenko, E. V. Kasparov, I. E. Kasparova,   +3 more
doaj   +1 more source

Oxidative stress: new insights on the association of nonalcoholic fatty liver disease and atherosclerosis [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to non-alcoholic steatohepatitis (NASH), which may progress ...
Albanese, Fabiana, Angelico, Francesco, Baratta, Francesco, DEL BEN, Maria, Pastori, Daniele, Perri, Ludovica, Polimeni, Licia, Violi, Francesco   +7 more
core   +1 more source

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Science Translational Medicine, 2020
A 25-gene expression signature associates with progression of fibrosing steatohepatitis in independent NAFLD cohorts. Gene expression during disease progression Nonalcoholic fatty liver disease (NAFLD) manifests as an array of conditions ranging from ...
O. Govaere, S. Cockell, D. Tiniakos, R. Queen, R. Younes, M. Vacca, L. Alexander, F. Ravaioli, J. Palmer, S. Petta, J. Boursier, C. Rosso, Katherine Johnson, Kristy Wonders, C. Day, M. Ekstedt, M. Orešič, R. Darlay, H. Cordell, F. Marra, A. Vidal-Puig, P. Bedossa, J. Schattenberg, K. Clément, M. Allison, E. Bugianesi, V. Ratziu, A. Daly, Q. Anstee   +28 more
semanticscholar   +1 more source

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

Metabolic dysfunction-associated fatty liver disease and metabolic-associated steatohepatitis: a review of pathogenesis and potential pharmacological targets

Fiyz̤, 2022
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most common liver diseases that results from excess fat accumulation in the hepatocytes. The progression of steatosis to hepatocellular necrosis and inflammation leads
Samaneh Olapour, Hamid Yaghooti
doaj  

The Benefit of Sleeve Gastrectomy in Obese Adolescents on Nonalcoholic Steatohepatitis and Hepatic Fibrosis [PDF]

, 2017
Objective To determine whether bariatric surgery is effective for the treatment of nonalcoholic steatohepatitis (NASH) in adolescence, we compared the efficacy of laparoscopic sleeve gastrectomy (LSG) with that of lifestyle intervention (nonsurgical ...
Alisi, Anna, Baumann, Ulrich, Caccamo, Romina, Cutrera, Renato, De Peppo, Francesco, De Stefanis, Cristiano, Giordano, Ugo, Manco, Melania, Mosca, Antonella, Nobili, Valerio, Silecchia, Gianfranco   +10 more
core   +1 more source

Trends in Characteristics, Mortality, and Other Outcomes of Patients With Newly Diagnosed Cirrhosis [PDF]

, 2019
Importance: Changes in the characteristics of patients with cirrhosis are likely to affect future outcomes and are important to understand in planning for the care of this population.
Chalasani, Naga, Desai, Archita, Ghabril, Marwan, Nephew, Lauren, Orman, Eric S., Patidar, Kavish, Roberts, Anna   +6 more
core   +1 more source