Results 51 to 60 of about 201,880 (241)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Investigations on Diamond-NV-Centers as Alternative Labels in STED Microscopy [PDF]

EPJ Web of Conferences
We investigate diamond nitrogen-vacancy (NV) centers as alternative labels in stimulated emission depletion (STED) microscopy. To this end, artificial diamond is used as a substrate and Raman spectroscopy in photoluminescence (PL) mode is performed for ...
Nouri Mohammad, Harm Gunilla, Olivero Paolo, Voß Tobias, Kroker Stefanie, Bodermann Bernd   +5 more
doaj   +1 more source

Localization STED (LocSTED) microscopy with 15 nm resolution

Nanophotonics, 2020
We present localization with stimulated emission depletion (LocSTED) microscopy, a combination of STED and single-molecule localization microscopy (SMLM).
Puthukodan Sujitha, Murtezi Eljesa, Jacak Jaroslaw, Klar Thomas A.   +3 more
doaj   +1 more source

Evaluation of sted super-resolution image quality by image correlation spectroscopy (QuICS)

Scientific Reports, 2021
Quantifying the imaging performances in an unbiased way is of outmost importance in super-resolution microscopy. Here, we describe an algorithm based on image correlation spectroscopy (ICS) that can be used to assess the quality of super-resolution ...
Elena Cerutti, Morgana D’Amico, Isotta Cainero, Gaetano Ivan Dellino, Mario Faretta, Giuseppe Vicidomini, Pier Giuseppe Pelicci, Paolo Bianchini, Alberto Diaspro, Luca Lanzanò   +9 more
doaj   +1 more source

Parallelized STED fluorescence nanoscopy

Optics Express, 2011
We introduce a parallelized STED microscope featuring m = 4 pairs of scanning excitation and STED beams, providing m-fold increased imaging speed of a given sample area, while maintaining basically all of the advantages of single beam scanning. Requiring only a single laser source and fiber input, the setup is inherently aligned both spatially and ...
Bingen, P., Reuss, M., Engelhardt, J., Hell, S. ; https://orcid.org/0000-0002-9638-5077   +3 more
openaire   +4 more sources

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

Effect of light polariztion on pattern illumination super-resolution imaging [PDF]

Journal of Innovative Optical Health Sciences, 2016
Far-field fluorescence microscopy has made great progress in the spatial resolution, limited by light diffraction, since the super-resolution imaging technology appeared.
Caimin Qiu, Jianling Chen, Zexian Hou, Chaoxian Xu, Shusen Xie, Hongqin Yang   +5 more
doaj   +1 more source

Challenges of intracellular visualization using virtual and augmented reality

Frontiers in Bioinformatics, 2022
Microscopy image observation is commonly performed on 2D screens, which limits human capacities to grasp volumetric, complex, and discrete biological dynamics. With the massive production of multidimensional images (3D + time, multi-channels) and derived
Cesar Augusto Valades-Cruz, Cesar Augusto Valades-Cruz, Ludovic Leconte, Ludovic Leconte, Gwendal Fouche, Gwendal Fouche, Gwendal Fouche, Thomas Blanc, Nathan Van Hille, Kevin Fournier, Kevin Fournier, Kevin Fournier, Tao Laurent, Benjamin Gallean, Francois Deslandes, Bassam Hajj, Emmanuel Faure, Ferran Argelaguet, Alain Trubuil, Tobias Isenberg, Jean-Baptiste Masson, Jean Salamero, Jean Salamero, Charles Kervrann, Charles Kervrann   +24 more
doaj   +1 more source

Fiber-integrated frequency-doubling of a picosecond Raman laser to 560 nm [PDF]

, 2015
We report the development of a fiber-integrated picosecond source at 560 nm by second harmonic generation of a Raman fiber laser. A picosecond ytterbium master oscillator power fiber amplifier is used to pulse-pump a Raman amplifier, which is seeded by a
kelleher, EJR, Legg, T, murray, RT, popov, SV, Runcorn, T, taylor, JR   +5 more
core   +1 more source