Results 71 to 80 of about 25,057 (234)
Challenges of intracellular visualization using virtual and augmented reality
Frontiers in Bioinformatics, 2022 Microscopy image observation is commonly performed on 2D screens, which limits human capacities to grasp volumetric, complex, and discrete biological dynamics. With the massive production of multidimensional images (3D + time, multi-channels) and derived
Cesar Augusto Valades-Cruz +24 more
doaj +1 more source
Advanced Science, EarlyView.The schematic diagram depicts a compartmentalized anti‐ferroptotic defense mechanism mediated by GSTA4. GSTA4 is upregulated and localizes to the cytoplasm in ENZR cells, where it detoxifies 4‐HNE via a non‐canonical GSH‐dependent pathway. Under oxidative stress, GSTA4 translocates to mitochondria, interacts with PGAM5, and blocks Drp1 Ser637 ...
Yong Luo +17 more
wiley +1 more source
Effect of light polariztion on pattern illumination super-resolution imaging [PDF]
Journal of Innovative Optical Health Sciences, 2016 Far-field fluorescence microscopy has made great progress in the spatial resolution, limited by light diffraction, since the super-resolution imaging technology appeared.
Caimin Qiu +5 more
doaj +1 more source
Ciliary Membrane Lipid Homeostasis in Health and Disease
Advanced Science, EarlyView.This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang +3 more
wiley +1 more source
, 2013 A) Confocal, B) STED and C) AFM images of a sample consisting of a mixture of 20 and 40 nm beads fluorescing crimson. D) The insights also show the distinctive population identifiable in STED and AFM, while confocal is limited by diffraction.
Claudio Canale (422538) +3 more
core +1 more source
AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells
Advanced Science, EarlyView.Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding +12 more
wiley +1 more source
Advanced Science, EarlyView.A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao +12 more
wiley +1 more source
STED systems in South Africa [PDF]
, 1996 STED systems in South ...
L.M. Austin (7218434)
core +4 more sources
A Novel Constitutional TUBB Variant Associated With Familial Malformations of Cortical Development
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Most pathogenic tubulin variants arise de novo in sporadic patients, causing severe brain malformations and significant neurodevelopmental impairment. The resulting reproductive disadvantage typically prevents these mutations from being transmitted to offspring.
Elena Cellini +9 more
wiley +1 more source
Sample Preparation for STED Microscopy [PDF]
, 2009 Since the discovery of the diffraction barrier in the late nineteenth century, it has been commonly accepted that with far-field optical microscopy it is not possible to resolve structural details considerably finer than half the wavelength of light. The emergence of STED microscopy showed that, at least for fluorescence imaging, these limits can be ...
Wurm, Christian Andreas +4 more
openaire +4 more sources