Results 61 to 70 of about 201,880 (241)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Removing Common Endings to Make Words [PDF]

, 2019
Pairs of words which end with the same group of letters have their common letter group removed so that the remaining letters form a ...
Thorpe, Susan
core   +1 more source

Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. [PDF]

, 2019
PGAM5 is a mitochondrial protein phosphatase whose genetic ablation in mice results in mitochondria-related disorders, including neurodegeneration. Functions of PGAM5 include regulation of mitophagy, cell death, metabolism and aging.
Agnew, Christopher, Frost, Adam, Herrera, Clara, Ingaramo, Maria, Jura, Natalia, Miller-Vedam, Lakshmi, Ruiz, Karen, Thaker, Tarjani M, Toso, Daniel, Trenker, Raphael   +9 more
core   +3 more sources

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Chromosome Segregation Is Biased by Kinetochore Size [PDF]

, 2018
Chromosome missegregation during mitosis or meiosis is a hallmark of cancer and the main cause of prenatal death in humans. The gain or loss of specific chromosomes is thought to be random, with cell viability being essentially determined by selection ...
Aguiar, P, Almeida, A C, Damas, J, Drpic, D, Khodjakov, A, Larkin, D M, Lewin, H A, Maiato, H, Renda, F   +8 more
core   +2 more sources

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Aberration correction for improving the image quality in STED microscopy using the genetic algorithm

Nanophotonics, 2018
With a purely optical modulation of fluorescent behaviors, stimulated emission depletion (STED) microscopy allows for far-field imaging with a diffraction-unlimited resolution in theory.
Wang Luwei, Yan Wei, Li Runze, Weng Xiaoyu, Zhang Jia, Yang Zhigang, Liu Liwei, Ye Tong, Qu Junle   +8 more
doaj   +1 more source

Six-Letter Connoisseur\u27s Ladders [PDF]

, 2001
By the time we reach six-letter words, conditions for superior ladders are much improved: nearly one-half of six-letter words are heterograms (all letters are different), the fraction of isolanos (words which have no neighbours) decreases to less than ...
Gooch, Rex
core   +2 more sources

Deterministic generation of an on-demand Fock state

, 2012
We theoretically study the deterministic generation of photon Fock states on-demand using a protocol based on a Jaynes Cummings quantum random walk which includes damping.
Acosta, Acosta, Barclay, Bassett, Batalov, Bracken, Brattke, Brown, Brune, Choy, Collett, Dayan, Demosthenes Ellinas, Ellinas, Filipowicz, Fu, Gardiner, Gavin K. Brennen, Gorodetsky, Grudinin, Grudinin, Guerlin, Hofheinz, Jason Twamley, Jelezko, Keyu Xia, Kok, Larsson, Law, Lee, Liu, Ma, Maze, Mazzei, Milburn, Mochalin, Park, Rittweger, Rivoire, Robledo, Robledo, Sansoni, Santos, Smith, Tamarat, Tamarat, Tan, Vahala, Varcoe, Vernooy, Yang, Zhu, Zhu   +52 more
core   +1 more source