Results 61 to 70 of about 25,057 (234)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Polarization effects in lattice–STED microscopy

, 2015
Massive parallelization of STED-like nanoscopies is now achievable using well-designed optical lattices for state depletion. Yet, only the lattice intensity distribution was considered for the description of the super-resolved point spread function ...
YANG, Bin, TREBBIA, Jean-Baptiste, TREUSSART, François, LOUNIS, Brahim, C.-Y., Fang, H.-C., Chang   +5 more
core   +1 more source

The optical near-field: super-resolution imaging with structural and phase correlation

Nanophotonics, 2014
An overview of near-field optics is presented with a focus on the fundamental advances that have been made in the field since its inception 30 years ago. A focus is placed on the advancements that have been achieved in instrumentation.
Lewis Aaron, Lev Dmitry, Sebag Daniel, Hamra Patricia, Levy Hadas, Bernstein Yirmi, Brahami Aaron, Tal Nataly, Goldstein Omri, Yeshua Talia   +9 more
doaj   +1 more source

The spatiotemporal electrogram dispersion ablation targeting rotors is more effective for elderly patients than non‐elderly population

Journal of Arrhythmia, 2023
Background Modulating atrial fibrillation (AF) drivers has been proposed as one of the effective ablation strategies for non‐paroxysmal AF (non‐PAF). However, the optimal non‐PAF ablation strategy is still under debate because the exact mechanisms of AF ...
Kensuke Sakata, Tomomi Tanaka, Soichiro Yamashita, Masanori Kobayashi, Mitsuaki Ito, Kohei Yamashiro   +5 more
doaj   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Investigations on Diamond-NV-Centers as Alternative Labels in STED Microscopy [PDF]

EPJ Web of Conferences
We investigate diamond nitrogen-vacancy (NV) centers as alternative labels in stimulated emission depletion (STED) microscopy. To this end, artificial diamond is used as a substrate and Raman spectroscopy in photoluminescence (PL) mode is performed for ...
Nouri Mohammad, Harm Gunilla, Olivero Paolo, Voß Tobias, Kroker Stefanie, Bodermann Bernd   +5 more
doaj   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Evaluation of sted super-resolution image quality by image correlation spectroscopy (QuICS)

Scientific Reports, 2021
Quantifying the imaging performances in an unbiased way is of outmost importance in super-resolution microscopy. Here, we describe an algorithm based on image correlation spectroscopy (ICS) that can be used to assess the quality of super-resolution ...
Elena Cerutti, Morgana D’Amico, Isotta Cainero, Gaetano Ivan Dellino, Mario Faretta, Giuseppe Vicidomini, Pier Giuseppe Pelicci, Paolo Bianchini, Alberto Diaspro, Luca Lanzanò   +9 more
doaj   +1 more source

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

Advanced Science, EarlyView.
Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu   +18 more
wiley   +1 more source

Scanning gP-STED nanoscopy images.

, 2013
Scanning images of microtubule of fixed PtK2 cells immunolabeled with the dye KK114 (A) and ATTO647N (B): confocal (left), time-gated gP-STED (middle left) and non-gated P-STED (middle right) images, and normalized intensity profiles along the arrows ...
Stefan W. Hell (101918), Gael Moneron (101912), Haisen Ta (101910), Christian Eggeling (101915), Giuseppe Vicidomini (101908), Andreas Schönle (101909), Kyu Young Han (101911)   +6 more
core   +1 more source