Results 111 to 120 of about 91,199 (294)

The High Energy X-ray Probe (HEX-P): probing accretion onto stellar mass black holes

Frontiers in Astronomy and Space Sciences
Accretion is a universal astrophysical process that plays a key role in cosmic history, from the epoch of reionization to galaxy and stellar formation and evolution. Accreting stellar-mass black holes in X-ray binaries are one of the best laboratories to
Riley M. T. Connors, John A. Tomsick, Paul Draghis, Benjamin Coughenour, Aarran W. Shaw, Javier A. García, Javier A. García, Dominic Walton, Kristin Madsen, Daniel Stern, Nicole Cavero Rodriguez, Thomas Dauser, Melania Del Santo, Jiachen Jiang, Henric Krawczynski, Honghui Liu, Joseph Neilsen, Michael Nowak, Sean Pike, Andrea Santangelo, Navin Sridhar, Navin Sridhar, Navin Sridhar, Andrew West, Jörn Wilms   +24 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Planet Formation Regulated by Galactic-scale Interstellar Turbulence

The Astrophysical Journal Letters
Planet formation occurs over a few Myr within protoplanetary disks of dust and gas, which are often assumed to evolve in isolation. However, extended gaseous structures have been uncovered around many protoplanetary disks, suggestive of late-stage infall
Andrew J. Winter, Myriam Benisty, Sean M. Andrews   +2 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Rotational Evolution of Classical T Tauri Stars: Models and Observations

The Astrophysical Journal
We developed a grid of stellar rotation models for low-mass and solar-type classical T Tauri stars (CTTS; 0.3 M _⊙ < M _* < 1.2 M _⊙ ). These models incorporate the star–disk interaction and magnetospheric ejections to investigate the evolution of the ...
Javier Serna, Giovanni Pinzón, Jesús Hernández, Ezequiel Manzo-Martínez, Karina Mauco, Carlos G. Román-Zúñiga, Nuria Calvet, Cesar Briceño, Ricardo López-Valdivia, Marina Kounkel, Guy S. Stringfellow, Keivan G. Stassun, Marc Pinsonneault, Lucia Adame, Lyra Cao, Kevin Covey, Amelia Bayo, Alexandre Roman-Lopes, Christian Nitschelm, Richard R. Lane   +19 more
doaj   +1 more source

The magnetospheric accretion/ejection process in young stellar objects: open issues and perspectives

EPJ Web of Conferences, 2014
This summary talk aims at highlighting some of the remaining open issues regarding the physics of the magnetospheric accretion/ejection process in young stellar objects (YSOs).
Bouvier J.
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Constraining Wind-driven Accretion onto Gaia BH3 with Chandra

The Astrophysical Journal
Gaia BH3 is the most massive known stellar-origin black hole in the Milky Way, with a mass M _• ≈ 33 M _⊙ . Detected from Gaia’s astrometry, this black hole is in the mass range of those observed via gravitational waves, whose nature is still highly ...
Nico Cappelluti, Fabio Pacucci, Günther Hasinger   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source