Results 111 to 120 of about 2,560 (288)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

SDSS. IV. MaNGA: The Impact of the Acquisition of Gas with Opposite Angular Momentum on the Evolution of Galaxies

The Astronomical Journal
A gaseous counterrotating galaxy is a galaxy containing a gas component with opposite angular momentum to the main stellar disk. The counterrotating gas provides direct evidence for the accretion of external material, a key aspect in hierarchical galaxy ...
Minje Beom, René A. M. Walterbos, Dmitry Bizyaev   +2 more
doaj   +1 more source

Stellar winds and accretion in HMXBs

, 2017
High Mass X-ray Binaries are excellent laboratories where current models of stellar winds and accretion physics can be tested. In this talk we will present XMM-Newton and Chandra observations of several HMXBs in order to explore the structure of the stellar wind of their massive star donors and its interplay with the accretion onto the neutron star. In
Torrejon, Jose M., Sanjurjo-Ferrín, Graciela, Postnov, Konstantin, Oskinova, Lidia M., Rodes Roca, José Joaquín, Bernabeu, Guillermo   +5 more
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

From Feast to Famine: A Systematic Study of Accretion onto Oblique Pulsars with 3D GRMHD Simulations

The Astrophysical Journal Letters
Disk-fed accretion onto neutron stars can power a wide range of astrophysical sources ranging from X-ray binaries, to accretion-powered millisecond pulsars, ultraluminous X-ray sources, and gamma-ray bursts.
Ariadna Murguia-Berthier, Kyle Parfrey, Alexander Tchekhovskoy, Jonatan Jacquemin-Ide   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Accretion of Active Galactic Nucleus Stars Under the Influence of Disk Geometry

The Astrophysical Journal
Massive stars can form within or be captured by active galactic nucleus disks, influencing both the thermal structure and metallicity of the disk environment.
Yi-Xian Chen, Yan-Fei Jiang, Jeremy Goodman   +2 more
doaj   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

A MaNGA about the Legacy. I. Connecting the Assembly of Stellar Halo with the Average Star Formation History in Low-redshift Massive Galaxies

The Astronomical Journal
We investigate the connection between stellar mass distribution, assembly history, and star formation timescales in low-redshift massive early-type galaxies (ETGs) by combining deep LegacySurvey imaging with MaNGA’s spatially resolved spectroscopy ...
Xiaoya Zhang, Song Huang, Meng Gu
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source