Results 91 to 100 of about 882,024 (358)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Accurate M Dwarf Metallicities from Spectral Synthesis: A Critical Test of Model Atmospheres [PDF]

, 2006
We describe a method for accurately determining M dwarf metallicities with spectral synthesis based on abundance analyses of visual binary stars. We obtained high resolution, high signal-to-noise spectra of each component of five visual binary pairs at ...
Bean, Jacob L., Benedict, G. Fritz, Hauschildt, Peter H., Johns-Krull, Christopher M., Sneden, Christopher   +4 more
core   +2 more sources

The classical stellar atmosphere problem

Journal of Computational and Applied Mathematics, 1999
accepted for publication in The Journal of Computational and Applied Mathematics, Computational Astrophysics, eds. H.
Werner, Klaus, Dreizler, Stefan
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Chromospheric Modeling of the Active M3V Star G 80–21 with RH1.5D

The Astrophysical Journal
This study investigates the active regions of the M3.0V star G 80–21 using the observed data from the CARMENES project with synthetic spectra generated by the RH1.5D radiative transfer code.
Shuai Liu, Huigang Wei, Jianrong Shi, Wenxian Li, Henggeng Han, Jifeng Liu, Shangbin Yang   +6 more
doaj   +1 more source

Stark Widths of Ar II Spectral Lines in the Atmospheres of Subdwarf B Stars

Atoms, 2017
Stark broadening parameters are of interest for many problems in astrophysics and laboratory plasmas investigation. Ar II spectral lines are observed in many kinds of stellar atmospheres such as the atmospheres of B-Type stars and subdwarf B stars.
Rafik Hamdi, Nabil Ben Nessib, Sylvie Sahal Bréchot, Milan S. Dimitrijević   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

JWST-TST DREAMS: Secondary Atmosphere Constraints for the Habitable Zone Planet TRAPPIST-1 e

The Astrophysical Journal Letters
The TRAPPIST-1 system offers one of the best opportunities to characterize temperate terrestrial planets beyond our own solar system. Within the TRAPPIST-1 system, planet e stands out as highly likely to sustain surface liquid water if it possesses an ...
Ana Glidden, Sukrit Ranjan, Sara Seager, Néstor Espinoza, Ryan J. MacDonald, Natalie H. Allen, Caleb I. Cañas, David Grant, Amélie Gressier, Kevin B. Stevenson, Natasha E. Batalha, Nikole K. Lewis, Douglas Long, Hannah R. Wakeford, Lili Alderson, Ryan C. Challener, Knicole Colón, Jingcheng Huang, Zifan Lin, Dana R. Louie, Elijah Mullens, Kristin S. Sotzen, Jeff A. Valenti, Daniel Valentine, Mark Clampin, C. Matt Mountain, Marshall Perrin, Roeland P. van der Marel   +27 more
doaj   +1 more source

LINE FORMATION IN SPECTRA OF X-RAY NOVAE

Odessa Astronomical Publications, 2017
Results of X-ray Novae (XN) optical spectra computation are presented. The continuum and Balmer line are calculated. The model of XN as a self-irradiated accretion disk is used.
V. F. Suleimanov, V. V. Shimansky
doaj   +1 more source