Results 101 to 110 of about 820,585 (334)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

On Inhomogeneous Stellar Atmospheres.

The Astrophysical Journal, 1961
The problem of a plane parallel stellar atmosphere is discussed in which there is isotropic scattering at any given optical depth but in which the albedo for single scattering varies with the optical depth. The general solution for the emergent intensity, when the upper and lower surfaces of the atmosphere are subjset to known incident radiation, is ...
openaire   +2 more sources

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

The Application of Mesoturbulence to Stellar Atmospheres [PDF]

International Astronomical Union Colloquium, 1980
AbstractFor realistic stellar atmospheres the equations describing mesoturbulent line formation are solved numerically. The general dependence of theoretical line profiles and equivalent widths on the correlation length 1 and the mean square turbulent velocity a is demonstrated.
openaire   +2 more sources

Inelastic silicon-hydrogen collision data for non-LTE applications in stellar atmospheres (cid:2)

, 2014
Aims. Inelastic processes in low-energy Si + H and Si + + H − collisions are treated for the states from the ground state up to the ionic state, in order to provide rate coe ffi cients needed for non-LTE modeling of Si in cool stellar atmospheres. Methods.
A. K. Belyaev, S. A. Yakovleva, P. Barklem   +2 more
semanticscholar   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Lithium and boron burning S(E)-factor measurements at astrophysical energies via the Trojan Horse Method

EPJ Web of Conferences, 2014
The residual amount of light elements lithium, beryllium and boron (LiBeB) abundances in stellar atmospheres has been largely accepted as one of the most powerful probes for understanding stellar structure and mixing phenomena. They are in fact gradually
Lamia L., Spitaleri C., Pizzone R. G., Cherubini S., Degl’Innocenti S., Grineviciute J., Gulino M., La Cognata M., Mukhamedzhanov A., Palmerini S., Pappalardo L., Prada Moroni P.G., Puglia S.M.R., Rapisarda G.G., Romano S., Sergi M.L., Tognelli E., Tumino A.   +17 more
doaj   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

THE EFFECTIVE TEMPERATURE DETERMINATION OF O-B STARS BY H AND He RADIO RECOMBINATION LINES OBSERVATIONS

Odessa Astronomical Publications, 2017
It is proposed to evaluate, on the basis of H and He radio recombination line observations, the number ratio of stellar photons, capable to ionize helium, to those capable to ionize hydrogen.
A. P. Tsivilev
doaj   +1 more source