Results 101 to 110 of about 71,994 (275)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Random Forest Classification of Stars in the Galactic Centre

, 2018
Near-infrared high-angular resolution imaging observations of the Milky Way's nuclear star cluster have revealed all luminous members of the existing stellar population within the central parsec. Generally, these stars are either evolved late-type giants
Plewa, P. M.
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Spectroscopic Survey of Metal-poor OB Stars in Local Dwarf Galaxy NGC 3109

The Astrophysical Journal
As JWST uncovers increasingly strong evidence that metal-poor, massive stars in early galaxies dominated reionization, observational constraints on the properties of such stars are more relevant than ever before.
Abby Mintz, O. Grace Telford, Evan N. Kirby, John Chisholm, Kristen B. W. McQuinn, Danielle A. Berg   +5 more
doaj   +1 more source

O stars and Wolf-Rayet stars [PDF]

Basic information is given about O and Wolf-Rayet stars indicating how these stars are defined and what their chief observable properties are. Part 2 of the volume discussed four related themes pertaining to the hottest and most luminous stars. Presented
Conti, Peter S., Jordan, Stuart, Thomas, Richard, Underhill, Anne B.   +3 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

45. Stellar Classification (Classification Stellaire) [PDF]

Transactions of the International Astronomical Union, 1994
D.J. MacConnel, R.O. Gray, C.B. Stephenson, M.J. Kurtz, J. Rountree, M. Grenon, D. Egret   +6 more
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Machine Learning Techniques to Distinguish Giant Stars from Dwarf Stars Using Only Photometry—Pushing Redward

The Astronomical Journal
We present our photometric method, which combines Subaru/Hyper Suprime-Cam N B 515, g -band, and i- band filters to distinguish giant stars in Local Group galaxies from Milky Way dwarf contamination.
Keyi Ding, Carrie Filion, Rosemary F.G. Wyse, Evan N. Kirby, Itsuki Ogami, Masashi Chiba, Yutaka Komiyama, László Dobos, Alexander S. Szalay   +8 more
doaj   +1 more source