Results 101 to 110 of about 2,400,614 (354)

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Probing the dusty stellar populations of the Local Volume Galaxies with JWST/MIRI

, 2017
The Mid-Infrared Instrument (MIRI) for the {\em James Webb Space Telescope} (JWST) will revolutionize our understanding of infrared stellar populations in the Local Volume.
Glasse, Alistair, Jones, Olivia C., Justtanont, Kay, Meixner, Margaret   +3 more
core   +1 more source

Classification of Astronomical Spectra Based on Multiscale Partial Convolution

The Astronomical Journal
The automated and efficient classification of astronomical spectra is an important research issue in the era of large sky surveys. Most current studies on automatic spectral classification primarily focus on specific data sets and demonstrate outstanding
Jingjing Wu, Yuchen He, Wenyu Wang, Meixia Qu, Bin Jiang, Yanxia Zhang   +5 more
doaj   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

A Spectroscopic Survey of Metal-poor OB Stars in Local Dwarf Galaxy NGC 3109

The Astrophysical Journal
As JWST uncovers increasingly strong evidence that metal-poor, massive stars in early galaxies dominated reionization, observational constraints on the properties of such stars are more relevant than ever before.
Abby Mintz, O. Grace Telford, Evan N. Kirby, John Chisholm, Kristen B. W. McQuinn, Danielle A. Berg   +5 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Mid-Infrared Galaxy Morphology Along the Hubble Sequence

, 2004
The mid-infrared emission from 18 nearby galaxies imaged with the IRAC instrument on Spitzer Space Telescope samples the spatial distributions of the reddening-free stellar photospheric emission and the warm dust in the ISM.
Block D. L., de Vaucouleurs G., de Vaucouleurs G., G. G. Fazio, M. L. N. Ashby, Michael A. Pahre, Naim A., S. P. Willner   +7 more
core   +2 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Classification of Stellar Spectral Data Using SVM [PDF]

, 2004
In this paper a new technique is developed on stellar spectral classification. Because stellar spectral data sets are usually extremely noisy, wavelet de-noising method is proposed to reduce noise first. Then the support vector machines (SVM) is used for the classification.
Ping Guo, Fei Xing
openaire   +2 more sources