Results 91 to 100 of about 4,432 (267)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Catalog of Distance Determinations for 5 Million Stars in LAMOST DR10

The Astronomical Journal
Using the distance estimation method outlined in J. L. Carlin et al., a Bayesian approach specifically tailored for LAMOST data, we estimated distances for 7,450,303 spectra from 5,394,174 unique stars in the LAMOST DR10 low-resolution data set.
Chengqun Yang, Xiang-Xiang Xue, Chao Liu, Hao Tian, Ling Zhu, Lan Zhang   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evolution of Stellar Activity and Habitable Zone. I. Ultraviolet Emission of Dwarfs in Open Clusters and Field Stars

The Astrophysical Journal Supplement Series
Near-ultraviolet (NUV) radiation from dwarf stars plays a critical role in shaping the habitability of planetary systems, yet its long-term evolution across different spectral types remains poorly investigated.
Xue Li, Song Wang, Jun Ma, Henggeng Han, Yang Huang, Jifeng Liu   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Absolute Age of Milky Way Globular Clusters

The Astrophysical Journal
Globular clusters (GCs) provide statistically significant coeval populations of stars spanning various evolutionary stages, allowing robust constraints on stellar evolution model parameters and ages.
Jiaqi (Martin) Ying, Brian Chaboyer, Michael Boylan-Kolchin, Daniel R. Weisz, Rowan Goebel-Bain   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Absolute Age of NGC 3201 Derived from Detached Eclipsing Binaries and the Hess Diagram

The Astrophysical Journal
We estimate the absolute age of the globular cluster NGC 3201 using 10,000 sets of theoretical isochrones constructed through Monte Carlo simulation using the Dartmouth Stellar Evolution Program.
Jiaqi (Martin) Ying, Brian Chaboyer, Wenxin Du   +2 more
doaj   +1 more source

A fresh look into the interaction of exoplanets magnetosphere with stellar winds using MHD simulations

Frontiers in Astronomy and Space Sciences
Numerous numerical studies have been carried out in recent years that simulate different aspects of exoplanets’ magnetosphere and stellar winds. These studies have focused primarily on hot Jupiters with sun-like stars. This study addresses the challenges
Fatemeh Bagheri, Fatemeh Bagheri, Ramon Lopez, Kevin Pham   +3 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source