Results 61 to 70 of about 182,216 (290)

M-dwarf stellar winds : the effects of realistic magnetic geometry on rotational evolution and planets [PDF]

, 2014
AAV acknowledges support from a Royal Astronomical Society Fellowship. JM acknowledges support from a fellowship of the Alexander von Humboldt foundation.We perform three-dimensional numerical simulations of stellar winds of early-M-dwarf stars.
Morin, J., Gombosi, T.I., Donati, J.F., Opher, M., Gombosi, Tamás, Jardine, M., Morin, Julien, Gombosi, T. I., Vidotto, A. A., Vidotto, A.A., Donati, J. F., Gombosi, Tamas I.   +11 more
core   +1 more source

Can Asteroseismic Structure Inversions Be Performed in Structure-dependent Coordinates?

The Astrophysical Journal
Unlike other applications of observational asteroseismology, “structure inversions” constrain the physical properties of stellar interiors in a model-independent fashion.
J. M. Joel Ong, Sarbani Basu, Willem B. Hoogendam, Vincent Vanlaer   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Revealing Mixed Modes in Compressible Hydrodynamical Simulations of Red Giant Stars

The Astrophysical Journal
Mixed modes are observed in many low-mass evolved stars. They provide information about core rotation rates of these stars, which are lower than predicted by stellar evolution models.
Nils B. de Vries, Arthur Le Saux, Isabelle Baraffe, Thomas Guillet, Richard H. D. Townsend, Armand Leclerc, Adrien Morison   +6 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The Impact of Breathing Pulses during Core Helium Burning on the Core Chemical Structure and Pulsations of Hydrogen-rich Atmosphere White Dwarfs

The Astrophysical Journal
Breathing pulses are mixing episodes that could develop during the core helium-burning phase of low- and intermediate-mass stars. The occurrence of breathing pulses is expected to bear consequences on the formation and evolution of white dwarfs ...
Alejandro H. Córsico, Leandro G. Althaus   +1 more
doaj   +1 more source

Impact of Newly Measured Nuclear Reaction Rates on ²⁶Al Ejected Yields from Massive Stars

Universe
Over the last three years, the rates of all the main nuclear reactions involving the destruction and production of 26Al in stars (26Al(n, p)26Mg, 26Al(n, α)23Na, 26Al(p, γ)27Si and 25Mg(p, γ)26Al) have been re-evaluated thanks to new high-precision ...
Umberto Battino, Lorenzo Roberti, Thomas V. Lawson, Alison M. Laird, Lewis Todd   +4 more
doaj   +1 more source