Results 121 to 130 of about 286,710 (351)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Exploring the Evolution of a Dwarf Spheroidal Galaxy with Smoothed-particle Hydrodynamics Simulations. I. Stellar Feedback

The Astrophysical Journal
A fundamental question regarding the evolution of dwarf spheroidal galaxies is the identification of the key physical mechanisms responsible for gas depletion.
Roberto Hazenfratz, Paramita Barai, Gustavo A. Lanfranchi, Anderson Caproni   +3 more
doaj   +1 more source

Variation in the Stellar Initial Mass Function from the Chromospheric Activity of M Dwarfs in Early-type Galaxies [PDF]

, 2021
Pieter van Dokkum, Charlie Conroy
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Census of Star Formation Histories of Massive Galaxies at 0.6 < z < 1 from Spectrophotometric Modeling Using Bagpipes and Prospector

The Astrophysical Journal
We present individual star formation histories (SFHs) of ∼3000 massive galaxies (log( M _* / M _⊙ ) > 10.5) from the Large Early Galaxy Astrophysics Census spectroscopic survey at a lookback time of ∼7 billion yr and quantify the population trends ...
Yasha Kaushal, Angelos Nersesian, Rachel Bezanson, Arjen van der Wel, Joel Leja, Adam Carnall, Anna Gallazzi, Stefano Zibetti, Gourav Khullar, Marijn Franx, Adam Muzzin, Anna de Graaff, Camilla Pacifici, Katherine E. Whitaker, Eric F. Bell, Marco Martorano   +15 more
doaj   +1 more source

Comparing Dark Energy Survey andHST–CLASH observations of the galaxy cluster RXC J2248.7−4431: implications for stellar mass versus dark matter [PDF]

, 2016
A. Palmese, O. Lahav, M. Banerji, D. Gruen, S. Jouvel, P. Melchior, J. Aleksić, J. Annis, H. T. Diehl, W. G. Hartley, T. Jeltema, A. K. Romer, Eduardo Rozo, E. S. Rykoff, S. Seitz, E. Suchyta, Y. Zhang, T. M. C. Abbott, F. B. Abdalla, S. Allam, A. Benoit-Lévy, E. Bertin, D. Brooks, E. Buckley‐Geer, D. L. Burke, D. Capozzi, A. Carnero Rosell, M. Carrasco Kind, J. Carretero, M. Crocce, C. E. Cunha, C. B. D’Andrea, L. da Costa, S. Desai, J. P. Dietrich, P. Doel, J. Estrada, A. E. Evrard, B. Flaugher, J. Frieman, D. W. Gerdes, D. A. Goldstein, R. A. Gruendl, G. Gutiérrez, K. Honscheid, D. J. James, K. Kuehn, N. Kuropatkin, Ting S. Li, M. Lima, M. A. G. Maia, J. L. Marshall, C. J. Miller, R. Miquel, B. Nord, R. L. C. Ogando, A. A. Plazas, A. Roodman, E. Sánchez, V. Scarpine, I. Sevilla-Noarbe, Rory Smith, M. Soares-Santos, F. Sobreira, M. E. C. Swanson, G. Tarlé, D. Thomas, D. L. Tucker, V. Vikram   +68 more
openalex   +1 more source

An empirical prediction for stellar metallicity distributions in nearby galaxies

, 2012
We combine star-formation histories derived from observations of high redshift galaxies with measurements of the z~0 relation between gas-phase metallicity, stellar mass, and star formation rate to make an explicit and completely empirical connection ...
Allende Prieto, Arrigoni, Asplund, Behroozi, Bensby, Bland-Hawthorn, Bouché, Brinchmann, Brooks, Brooks, Bruzual, Chabrier, Colavitti, Conroy, Daddi, Davé, Davé, Dayal, De Lucia, De Lucia, Delahaye, Dolphin, Eisenstein, Elbaz, Ellison, Ellison, Erb, Finlator, Fontanot, Gallazzi, Gallazzi, Garnett, Hirschmann, Hughes, Ivezić, Karim, Kewley, Kewley, Kimm, Kirby, Kirby, Kirby, Klypin, Kobayashi, Kobulnicky, Kormendy, Lara-López, Leitner, Leitner, Lopez-Sanchez, Lynden-Bell, Maiolino, Mannucci, Mannucci, Molly S. Peeples, Moster, Mouhcine, Nagashima, Nicholls, Noeske, Oliver, Oppenheimer, Pagel, Pasquali, Pasquali, Peeples, Rachel S. Somerville, Robaina, Salim, Savaglio, Scannapieco, Shapley, Skelton, Somerville, Sommariva, Spitoni, Thomas, Tinsley, Tinsley, Tissera, Toomre, Trager, Tremonti, Tumlinson, Weisz, Wiersma, Woo, Yabe, Yates, Zahid, Zahid, Zaritsky, Zheng   +92 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Recurrent gas accretion by massive star clusters, multiple stellar populations and mass thresholds for spheroidal stellar systems [PDF]

, 2009
Jan Pflamm-Altenburg, Pavel Kroupa
openalex   +1 more source

The SL2S Galaxy-scale Lens Sample. V. Dark Matter Halos and Stellar IMF of Massive Early-type Galaxies out to Redshift 0.8

, 2014
We investigate the cosmic evolution of the internal structure of massive early-type galaxies over half of the age of the Universe. We perform a joint lensing and stellar dynamics analysis of a sample of 81 strong lenses from the SL2S and SLACS surveys ...
Auger, Matthew W., Gavazzi, Raphael, Marshall, Philip J., Nipoti, Carlo, Sonnenfeld, Alessandro, Suyu, Sherry H., Treu, Tommaso   +6 more
core   +3 more sources