Results 111 to 120 of about 409,343 (365)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Simulated Coronal Mass Ejections on a Young Solar-type Star and the Associated Instantaneous Angular Momentum Loss

The Astrophysical Journal
Coronal mass ejections (CMEs) on stars can change the stars’ magnetic field configurations and mass-loss rates during the eruption and propagation and therefore, may affect the stars’ rotation properties on long timescales.
Yu Xu, Julián D. Alvarado-Gómez, Hui Tian, Katja Poppenhäger, Gustavo Guerrero, Xianyu Liu   +5 more
doaj   +1 more source

The Real-Time Evolution of V4334 Sgr

Galaxies, 2018
V4334 Sgr (Sakurai’s object) is an enigmatic evolved star that underwent a very late thermal pulse a few years before its discovery in 1996. It ejected a new hydrogen-deficient nebula in the process. The source has been observed continuously since,
Peter A. M. van Hoof, Stefan Kimeswenger, Griet C. Van de Steene, Adam Avison, Albert A. Zijlstra, Lizette Guzman-Ramirez, Falk Herwig, Marcin Hajduk   +7 more
doaj   +1 more source

Mass loss and supernova progenitors

, 2007
We first discuss the mass range of type IIP SN progenitors and how the upper and lower limits impose interesting constraints on stellar evolution. Then we discuss the possible implications of two SNe, 2002ap and 2006jc, for Wolf-Rayet star mass-loss ...
Christopher A. Tout, Guenter Houdek, John Eldridge, Rebecca G. Martin, Richard J. Stancliffe   +4 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

3-D radiative transfer in clumped hot star winds I. Influence of clumping on the resonance line formation

, 2012
The true mass-loss rates from massive stars are important for many branches of astrophysics. For the correct modeling of the resonance lines, which are among the key diagnostics of stellar mass-loss, the stellar wind clumping turned out to be very ...
A. Feldmeier, Avery, B. Šurlan, Bouret, Bouret, Box, Caroff, Castor, Cranmer, Dessart, Dessart, Eversberg, Feldmeier, Feldmeier, Feldmeier, Feldmeier, Fullerton, Hamann, Hamann, Hamann, Hamann, Hamann, Hillier, J. Kubát, Korčáková, Korčáková, Krtička, Krtička, L. M. Oskinova, Lobel, Lucy, Lucy, Lucy, Lépine, Lépine, Maeder, Markova, Muijres, Mullan, Oskinova, Oskinova, Oskinova, Owocki, Owocki, Owocki, Pauldrach, Prinja, Prinja, Prinja, Puls, Puls, Runacres, Sundqvist, Sundqvist, W.-R. Hamann, Waldron, Whitney, Zsargó   +57 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Modeling the Progenitor Stars of Observed Type IIP Supernovae

The Astrophysical Journal
Type IIP supernovae (SNe IIP) are thought to originate from the explosion of massive stars >10 M _⊙ . Their luminosity is primarily powered by the explosion energy and the radioactive decay energy of ^56 Co, with the photosphere location regulated by ...
Kai-An You, Ke-Jung Chen, Yen-Chen Pan, Sung-Han Tsai, Po-Sheng Ou   +4 more
doaj   +1 more source

Effects of tidally enhanced stellar wind on the horizontal branch morphology of globular clusters

, 2012
Metallicity is the first parameter to influence the horizontal branch (HB) morphology of globular clusters (GCs). It has been found, however, that some other parameters may also play an important role in affecting the morphology.
Chen, Xue-Fei, Han, Z., Lei, Zhen-Xin, Zhang, Feng-Hui   +3 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source