Results 151 to 160 of about 143,610 (241)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Luminosity and Stellar Mass Functions of Faint Photometric Satellites around Spectroscopic Central Galaxies from DESI Year-1 Bright Galaxy Survey

The Astrophysical Journal
We measure the luminosity functions (LFs) and stellar mass functions (SMFs) of photometric satellite galaxies around spectroscopically identified isolated central galaxies (ICGs). The photometric satellites are from the DESI Legacy Imaging Surveys (DR9),
Wenting Wang, Xiaohu Yang, Yipeng Jing, Ashley J. Ross, Malgorzata Siudek, John Moustakas, Samuel G. Moore, Shaun Cole, Carlos Frenk, Jiaxi Yu, Sergey E. Koposov, Jiaxin Han, Zhenlin Tan, Kun Xu, Yizhou Gu, Yirong Wang, Oleg Y. Gnedin, Jessica Nicole Aguilar, Steven Ahlen, Davide Bianchi, David Brooks, Todd Claybaugh, Axel de la Macorra, Arjun Dey, Peter Doel, Jaime E. Forero-Romero, Enrique Gaztañaga, Satya Gontcho A Gontcho, Gaston Gutierrez, Klaus Honscheid, Mustapha Ishak, Theodore Kisner, Martin Landriau, Laurent Le Guillou, Marc Manera, Aaron Meisner, Ramon Miquel, Seshadri Nadathur, Claire Poppett, Francisco Prada, Ignasi Pérez-Ràfols, Graziano Rossi, Eusebio Sanchez, David Schlegel, Hee-Jong Seo, Joseph Harry Silber, David Sprayberry, Gregory Tarlé, Benjamin Alan Weaver, Hu Zou   +49 more
doaj   +1 more source

Hubble Residuals of Nearby Type Ia Supernovae Are Correlated with Host Galaxy Masses

, 2010
From Sloan Digital Sky Survey u'g'r'i'z' imaging, we estimate the stellar masses of the host galaxies of 70 low redshift SN Ia (0.015 < z < 0.08) from the hosts' absolute luminosities and mass-to-light ratios.
Abazajian, Blanton, Blanton, Conley, Conley, Cooper, David L. Burke, Eisenstein, Filippenko, Fioc, Fioc, Gallagher, Gallagher, Hicken, Hicken, Howell, Ivanov, Jha, Kaisey S. Mandel, Kasen, Kasen, Kelly, Kelly, Kessler, Komatsu, Kowalski, Lair, Malcolm Hicken, Mandel, Matheson, Mukherjee, Neill, Patrick L. Kelly, Perlmutter, Pozzetti, Prieto, Rana, Raskin, Riess, Riess, Riess, Riess, Robert P. Kirshner, Scannapieco, Schlegel, Shaw, Sullivan, Timmes, Tremonti, Truran, Wang, Wood-Vasey, Wood-Vasey, York   +53 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Shape of FIREbox Galaxies and a Potential Tension with Low-mass Disks

The Astrophysical Journal
We study the intrinsic and observable shapes of approximately 700 star-forming galaxies with stellar masses of 10 ^8 –10 ^11 M _⊙ from the FIREbox simulation at z = 0.
Courtney Klein, Jenny D. Wang, Luke Y. Xia, James S. Bullock, Jorge Moreno, Robert Feldmann, Francisco J. Mercado, Claude-André Faucher-Giguère, Jonathan Stern, N. Nicole Sanchez, Abdelaziz Hussein, Michelle S. Park   +11 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Massive Star Cluster Formation with Binaries. I. Evolution of Binary Populations

The Astrophysical Journal
We study the evolution of populations of binary stars within massive cluster-forming regions. We simulate the formation of young massive star clusters within giant molecular clouds with masses ranging from 2 × 10 ^4 to 3.2 × 10 ^5 M _⊙ .
Claude Cournoyer-Cloutier, Alison Sills, William E. Harris, Brooke Polak, Steven Rieder, Eric P. Andersson, Sabrina M. Appel, Mordecai-Mark Mac Low, Stephen McMillan, Simon Portegies Zwart   +9 more
doaj   +1 more source